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Astaxanthin delayed the pathogenesis of diabetic nephropathy in type 1 diabetic rats

LIANHUAN MA1, SHOUPENG LIU2, XIAOWEN ZHEN1, WEIWEI QIAO1, LINA MA1, XIAOMIN ZHANG3,*

1 Department of Diagnostics, The Second School of Clinical Medicine, Binzhou Medical University, Yantai, 264003, China
2 School of Public Health and Management, Binzhou Medical University, Yantai, 264003, China
3 Department of Nephrology, Binzhou Medical University Hospital, Binzhou, 256603, China

* Corresponding Author: Xiaomin Zhang, email

(This article belongs to the Special Issue: Single Cell Technologies and Molecular Mechanisms of Diseases)

BIOCELL 2022, 46(8), 1911-1916. https://doi.org/10.32604/biocell.2022.019277

Abstract

This study was designed to investigate the protective effects of Astaxanthin (AST) in rats with diabetes mellitus (DM) induced by streptozotocin. SD rats were divided into control group (n = 5, only received normal saline), DM group (n = 8) and AST + DM group (n = 8; AST: 50 mg/kg/day). DM rats were induced by intraperitoneal injection of streptozocin (STZ, 65 mg/kg). Blood glucose level and body weight were determined at weeks 0, 2, 4, 6 and 8, respectively. At week 8, kidney function was determined, together with expression of P53 and dynamin-related protein-1 (Drp1) by Western blot analysis and immunofluorescence. AST led to increase of body weight in rats with DM. AST + DM group showed a significant decrease in blood glucose level at week 4 compared with DM group (P < 0.05). AST improved renal function and significantly reduced expression of P53 and Drp1 in DM rats. In addition, AST can effectively reduce the blood glucose in DM rats, and delayed the pathogenesis of diabetic nephropathy. Such delay mediated by AST may be associated with the downregulation of Drp1 and P53.

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APA Style
MA, L., LIU, S., ZHEN, X., QIAO, W., MA, L. et al. (2022). Astaxanthin delayed the pathogenesis of diabetic nephropathy in type 1 diabetic rats. BIOCELL, 46(8), 1911-1916. https://doi.org/10.32604/biocell.2022.019277
Vancouver Style
MA L, LIU S, ZHEN X, QIAO W, MA L, ZHANG X. Astaxanthin delayed the pathogenesis of diabetic nephropathy in type 1 diabetic rats. BIOCELL . 2022;46(8):1911-1916 https://doi.org/10.32604/biocell.2022.019277
IEEE Style
L. MA, S. LIU, X. ZHEN, W. QIAO, L. MA, and X. ZHANG "Astaxanthin delayed the pathogenesis of diabetic nephropathy in type 1 diabetic rats," BIOCELL , vol. 46, no. 8, pp. 1911-1916. 2022. https://doi.org/10.32604/biocell.2022.019277



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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