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Clinical implication of naive and memory T cells in locally advanced cervical cancer: A proxy for tumor biology and short-term response prediction

YUTING WANG1,2,3, PEIWEN FAN1,2,3, YANING FENG1,2,3, XUAN YAO4, YANCHUN PENG4, RUOZHENG WANG1,2,3,*

1 Key Laboratory of Cancer Immunotherapy and Radiotherapy, Chinese Academy of Medical Sciences, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China
2 Key Laboratory of Oncology of Xinjiang Uyghur Autonomous Region, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China
3 State Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia, The Third Affiliated Hospital of Xinjiang Medical University, Urumqi, China
4 Chinese Academy of Medical Sciences Oxford Institute (CAMS Oxford Institute), University of Oxford, Oxford, UK

* Corresponding Author: Ruozheng Wang, email

BIOCELL 2023, 47(6), 1365-1375. https://doi.org/10.32604/biocell.2023.027201

Abstract

Background: This study was designed to investigate the feasibility of tumor-infiltrating immune cells with different phenotypic characteristics for predicting short-term clinical responses in patients with locally advanced cervical cancer (LACC). Methods: Thirty-four patients who received concurrent chemoradiotherapy and twenty-one patients who merely underwent radiotherapy were enrolled in this study. We retrospectively analyzed the T cell markers (i.e., CD3, CD4, CD8), memory markers (i.e., CD45, CCR7), and differentiation markers (i.e., CD27) in the peripheral blood and tumor tissues of patients with LACC before treatment based on flow cytometry. We also analyzed the relationship of T cell subsets between peripheral blood and tumor tissues, and their correlation with complete response or partial response. Results: The percentage of central memory CD8+ TCM (CD8+ CD45RA CD27+ CCR7+ ) cells in LACC patients was significantly lower than that of the control group. The percentage of CD8+ TN in the peripheral blood of LACC patients was significantly higher than that of tumor tissues. CD8+ TEM in the peripheral blood was significantly lower than that of tumor tissues. The percentage of CD8+ TN and CD8+ TCM in human papillomavirus (HPV) positive samples was significantly higher than that of HPV-negative samples. Similarly, the percentage of CD8+ TCM in tumor tissues was significantly higher in cancer tissue samples with lymph nodes compared with those without. Conclusion: A higher proportion of CD4+ TCM and a lower proportion of CD8+ TN in the tumor microenvironment of LACC may contribute to the therapy response prediction.

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APA Style
WANG, Y., FAN, P., FENG, Y., YAO, X., PENG, Y. et al. (2023). Clinical implication of naive and memory T cells in locally advanced cervical cancer: A proxy for tumor biology and short-term response prediction. BIOCELL, 47(6), 1365-1375. https://doi.org/10.32604/biocell.2023.027201
Vancouver Style
WANG Y, FAN P, FENG Y, YAO X, PENG Y, WANG R. Clinical implication of naive and memory T cells in locally advanced cervical cancer: A proxy for tumor biology and short-term response prediction. BIOCELL . 2023;47(6):1365-1375 https://doi.org/10.32604/biocell.2023.027201
IEEE Style
Y. WANG, P. FAN, Y. FENG, X. YAO, Y. PENG, and R. WANG "Clinical implication of naive and memory T cells in locally advanced cervical cancer: A proxy for tumor biology and short-term response prediction," BIOCELL , vol. 47, no. 6, pp. 1365-1375. 2023. https://doi.org/10.32604/biocell.2023.027201



cc Copyright © 2023 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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