Open Access

COMMENTARY

Docosahexaenoic Acid (DHA) as a Nutritional Determinant of Cognitive Aging: A Hippocampal-Centric Commentary

Roland Mangold, Timea Teglas^*

Research Institute of Sport Science, Hungarian University of Sports Science, Budapest, H-1123, Hungary

* Corresponding Author: Timea Teglas. Email:

(This article belongs to the Special Issue: Cellular and Molecular Mechanisms Linking Nutrition to Brain Health and Cognitive Longevity)

BIOCELL 2025, 49(12), 2239-2244. https://doi.org/10.32604/biocell.2025.069925

Received 03 July 2025; Accepted 10 October 2025; Issue published 24 December 2025

Abstract

The quality of life in older adulthood is greatly influenced by cognitive aging, which in turn is affected by nutrition, especially as it relates to hippocampal function. Although the link between hippocampal function and nutrition is defined, the exact mechanics are still unknown. The commentary addresses how docosahexaenoic acid (DHA) contributes to age-related cognitive decline and may play a role in promoting neurogenesis and neuroplasticity on the molecular level. The current challenge to our understanding is to investigate how DHA influences hippocampal function and cognitive aging, which would be possible and even more detailed with the investigation of the mechanisms of signaling pathways. We also discuss what types of future studies are needed to clarify the mechanisms, optimal conditions, and individual factors influencing the hippocampal effects of DHA supplementation.

---

Keywords

---