Guest Editors
Dr. Timea Teglas
Email: teglas.timea@tf.hu
Affiliation: Research Institute of Sport Science, Hungarian University of Sports Science, H-1123 Budapest, Hungary
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Research Interests: neurodegeneration, cognitive decline, nutrition, aging, brain health, neuroinflammation, neurogenesis, mitochondria
Summary
Maintaining cognitive function and brain health across the lifespan is a major biomedical challenge in aging societies. Emerging evidence highlights the critical role of nutrition—particularly functional foods and bioactive nutrients—in modulating neurological health. However, the underlying cellular and molecular mechanisms through which nutrients influence brain function remain incompletely understood. This special issue of BIOCELL seeks to consolidate research focused on how nutrition interfaces with the molecular biology of neural cells, contributing to the understanding and potential prevention or slowing of neurodegenerative processes of cognitive decline and neurodegenerative conditions.
We welcome original research articles, reviews, and short communications that explore cell-level responses to dietary interventions, with a focus on mechanisms relevant to cognitive performance, neuroprotection, and brain aging. Studies employing in vitro cellular models, in vivo systems, or omics-based molecular profiling are particularly encouraged. Specific areas of interest include:
·Neuronal Signaling Pathways and Nutrient Modulation: Investigations into how vitamins, polyphenols, fatty acids, or other phytochemicals or nutrient-derived monomers affect intracellular signaling cascades—such as MAPK, PI3K/Akt, AMPK, or Nrf2—in neurons and glial cells, with emphasis on pathways relevant to cell survival, synaptic plasticity, inflammation, and redox regulation.
·Synaptic Plasticity and Neurogenesis: Studies exploring how dietary compounds modulate synaptic formation, maintenance, or regeneration, as well as the regulation of adult neurogenesis at the molecular level.
·Neuroinflammation and Oxidative Stress: Research focusing on how functional foods modulate inflammatory cytokine expression, microglial activation, or cellular redox balance.
·Mitochondrial Dynamics and Energy Metabolism: Nutritional influences on neuronal mitochondrial biogenesis, mitophagy, and ATP production.
·Epigenetic and Transcriptional Regulation: Studies on how diet alters DNA methylation, histone modifications, or non-coding RNA expression related to brain function.
·Gut-Brain Axis and Cellular Communication: Insights into microbiota-derived metabolites and their cellular targets in the central nervous system.
By combining advances in functional nutrition with the tools of cell biology and molecular neuroscience, this special issue aims to deepen our understanding of how dietary strategies may support cognitive longevity at the cellular level.
Keywords
brain health, functional nutrition, cognitive longevity, molecular mechanisms, neuroinflammation, synaptic plasticity, neuronal signaling, cellular metabolism
Published Papers
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