Open Access

REVIEW

The Role of the Progesterone Receptor Family in Alzheimer’s Disease

Taiyang Zhu¹, Fang Hua^2,*

1 Department of Neurology, Xuzhou Medical University, Xuzhou, 221004, China
2Division of Human Anatomy, College of Allied Health Science, Augusta University, Augusta, GA 30912, USA

* Corresponding Author: Fang Hua. Email:

(This article belongs to the Special Issue: Advances in Cellular and Molecular Mechanisms and Therapeutic Strategies for Neurodegenerative Diseases)

BIOCELL 2025, 49(7), 1169-1184. https://doi.org/10.32604/biocell.2025.064879

Received 26 February 2025; Accepted 18 April 2025; Issue published 25 July 2025

Abstract

Alzheimer’s disease (AD) is a neurological disorder characterized primarily by a progressive decline in cognitive and behavioral functions. The pathogenesis of AD has not been fully elucidated till now. The progesterone receptor (PR) family has recently attracted increasing attention and has become the focus of potential links to factors such as the pathogenesis and pathological changes of AD due to its role in the central nervous system. This article summarizes the progress of research progress on the PR family in AD, including its role in pathophysiology, molecular mechanisms, and potential therapeutic strategies.

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Keywords

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