Open Access

ARTICLE

Evaluation of systemic microvascular reactivity in adults with congenital heart disease

Pablo Marino^1,2, Gabriella de Oliveira Lopes^1,3, Juliana Pereira Borges³, Maria Carolina Terra Cola¹, Daniel Arkader Kopiler¹, Eduardo Tibirica¹

1 National Institute of Cardiology, Rio de Janeiro, Brazil
2 Antônio Pedro University Hospital, Federal Fluminense University, Niteroi, Brazil
3 Laboratory of Physical Activity and Health Promotion, Department of Collective Sports, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro, Brazil

* Corresponding Author: Eduardo Tibirica, Instituto Nacional de Cardiologia, Rua das Laranjeiras, 374, ZIP code 22240‐006, Rio de Janeiro, Brazil. Email:

Congenital Heart Disease 2018, 13(6), 978-987. https://doi.org/10.1111/chd.12660

Abstract

Objective: Adults with congenital heart disease share some features with those with chronic heart failure. Although microvascular endothelial dysfunction has been de‐ scribed in chronic heart failure, evaluation of the microcirculation in adults with con‐ genital heart disease is lacking. The present study aimed to investigate systemic microvascular reactivity in adults with congenital heart disease.
Interventions: The patients initially underwent cardiopulmonary exercise testing. Then, the cutaneous microvascular reactivity was evaluated in these patients using a laser speckle contrast imaging system coupled with skin iontophoresis of endothelial‐de‐ pendent (acetylcholine) or ‐independent (sodium nitroprusside) vasodilators and pos‐ tocclusive reactive hyperemia (PORH) and compared with healthy controls matched for age and sex.
Results: Thirty‐one patients and 29 healthy controls were evaluated. The basal micro‐ vascular flow (P < .0001) and area under the curve in response to acetylcholine (P < .0001) were higher in the patients than in the healthy volunteers. The increase in cutaneous vascular conductance in response to sodium nitroprusside was reduced in the patients compared to the healthy volunteers (P = .0031). No difference in the micro‐ vascular response was observed during postocclusive reactive hyperemia. The basal microvascular flow of patients with peak oxygen consumption below 16.0 mL kg^‐1 min^‐1 was superior to that of patients with values greater than 16.0 mL kg^‐1 min^‐1 (P = .0046).
Conclusions: Adults with congenital heart disease present a higher baseline cutaneous microvascular blood flow than healthy controls and do not present systemic microvas‐ cular endothelial dysfunction. Nevertheless, endothelium‐independent microvascular reactivity is blunted, suggesting an altered vascular smooth muscle response or vascu‐ lar structural alterations. Finally, patients with a lower functional capacity presented a greater microvascular basal blood flow than subjects with a higher functional capacity.

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