Pablo Marino1,2, Gabriella de Oliveira Lopes1,3, Juliana Pereira Borges3, Maria Carolina Terra Cola1, Daniel Arkader Kopiler1, Eduardo Tibirica1
Congenital Heart Disease, Vol.13, No.6, pp. 978-987, 2018, DOI:10.1111/chd.12660
Abstract Objective: Adults with congenital heart disease share some features with those with
chronic heart failure. Although microvascular endothelial dysfunction has been de‐
scribed in chronic heart failure, evaluation of the microcirculation in adults with con‐
genital heart disease is lacking. The present study aimed to investigate systemic
microvascular reactivity in adults with congenital heart disease.
Interventions: The patients initially underwent cardiopulmonary exercise testing. Then,
the cutaneous microvascular reactivity was evaluated in these patients using a laser
speckle contrast imaging system coupled with skin iontophoresis of endothelial‐de‐
pendent (acetylcholine) or ‐independent (sodium nitroprusside) vasodilators and pos‐
tocclusive reactive hyperemia (PORH) and… More >
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