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3D Semantic Deep Learning Networks for Leukemia Detection

Javaria Amin1, Muhammad Sharif2, Muhammad Almas Anjum3, Ayesha Siddiqa1, Seifedine Kadry4, Yunyoung Nam5,*, Mudassar Raza2

1 University of Wah, Wah Cantt, Pakistan
2 COMSATS University Islamabad, Wah Campus, Pakistan
3 National University of Technology (NUTECH), IJP Road Islamabad, Pakistan
4 Faculty of Applied Computing and Technology, Noroff University College, Kristiansand, Norway
5 Department of Computer Science and Engineering, Soonchunhyang University, Asan, 31538, Korea

* Corresponding Author: Yunyoung Nam. Email:

(This article belongs to this Special Issue: AI, IoT, Blockchain Assisted Intelligent Solutions to Medical and Healthcare Systems)

Computers, Materials & Continua 2021, 69(1), 785-799.


White blood cells (WBCs) are a vital part of the immune system that protect the body from different types of bacteria and viruses. Abnormal cell growth destroys the body’s immune system, and computerized methods play a vital role in detecting abnormalities at the initial stage. In this research, a deep learning technique is proposed for the detection of leukemia. The proposed methodology consists of three phases. Phase I uses an open neural network exchange (ONNX) and YOLOv2 to localize WBCs. The localized images are passed to Phase II, in which 3D-segmentation is performed using deeplabv3 as a base network of the pre-trained Xception model. The segmented images are used in Phase III, in which features are extracted using the darknet-53 model and optimized using Bhattacharyya separately criteria to classify WBCs. The proposed methodology is validated on three publically available benchmark datasets, namely ALL-IDB1, ALL-IDB2, and LISC, in terms of different metrics, such as precision, accuracy, sensitivity, and dice scores. The results of the proposed method are comparable to those of recent existing methodologies, thus proving its effectiveness.


Cite This Article

J. Amin, M. Sharif, M. Almas Anjum, A. Siddiqa, S. Kadry et al., "3d semantic deep learning networks for leukemia detection," Computers, Materials & Continua, vol. 69, no.1, pp. 785–799, 2021.


cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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