Open Access

ARTICLE

Fast Force Loading Disrupts Molecular Binding Stability in Human and Mouse Cell Adhesions

Yunfeng Chen^1,2,3,†,*, Jiexi Liao^4,†, Zhou Yuan¹, Kaitao Li⁴, Baoyu Liu⁴, Lining Arnold Ju^4,5,6, Cheng Zhu^1,2,4,*

1 Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA.
2 Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA.
3 Department of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, The Scripps Research Institute, La Jolla, California, 92037, USA.
4 Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA.
5 Heart Research Institute, University of Sydney, Camperdown, NSW 2006, Australia.
6 Charles Perkins Centre, tUniversity of Sydney, Camperdown, NSW 2006, Australia.
† These authors contributed equally.

* Corresponding Authors:* Correspondence Authors: Yunfeng Chen. Email: ; Cheng Zhu. Email: .