Home / Journals / MCB / Vol.16, No.3, 2019
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  • Open Access

    ARTICLE

    Warmest Congratulations to Dr. Yuan-Cheng Fung at His Centennial Celebration

    Shu Chien*
    Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 163-178, 2019, DOI:10.32604/mcb.2019.07689
    Abstract Professor Y.C. Fung has made tremendous impacts on science, engineering and humanity through his research and its applications, by setting the highest standards, through educating many students and their students, and providing his exemplary leadership. He has applied his profound knowledge and elegant analytical methods to the study of biomedical problems with rigor and excellence. He established the foundations of biomechanics in living tissues and organs. Through his vision of the power of “making models” to explain and predict biological phenomena, Dr. Fung opened up new vista for bioengineering, from organs-systems to molecules-genes, and has provided the foundation of research… More >

  • Open Access

    ARTICLE

    A Novel Atlas-Based Strategy for Understanding Cardiac Dysfunction in Patients with Congenital Heart Disease

    Sara Salehyar1, †, Nickolas Forsch1,†,*, Kathleen Gilbert2,3, Alistair A. Young3,4, James C. Perry5, Sanjeet Hegde5, Jeffrey H. Omens1,6, Andrew D. McCulloch1,6
    Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 179-183, 2019, DOI:10.32604/mcb.2019.07384
    Abstract Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease. Infants diagnosed with TOF require surgical interventions to survive into adulthood. However, as a result of postoperative structural malformations and long-term ventricular remodeling, further interventions are often required later in life. To help identify those at risk of disease progression, serial cardiac magnetic resonance (CMR) imaging is used to monitor these patients. However, most of the detailed information on cardiac shape and biomechanics contained in these large four-dimensional (4D) data sets goes unused in clinical practice for lack of efficient and comprehensive quantitative analysis tools. While… More >

  • Open Access

    ARTICLE

    Intramyocardial Injections to De-Stiffen the Heart: A Subject-Specific in Silico Approach

    Yaghoub Dabiri1,3, Kevin L. Sack1,2, Semion Shaul1, Gabriel Acevedo-Bolton1, Jenny S. Choy3, Ghassan S. Kassab3, Julius M. Guccione1,*
    Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 185-197, 2019, DOI:10.32604/mcb.2019.07364
    Abstract We hypothesized that minimally invasive injections of a softening agent at strategic locations in stiff myocardium could de-stiffen the left ventricle (LV) globally. Physics-based finite element models of the LV were created from LV echocardiography images and pressures recorded during experiments in four swine. Results confirmed animal models of LV softening by systemic agents. Regional de-stiffening of myocardium led to global de-stiffening of LV. The mathematical set up was used to design LV global de-stiffening by regional softening of myocardium. At an end diastolic pressure of 23 mmHg, when 8 ml of the free wall was covered by intramyocardial injections,… More >

  • Open Access

    ARTICLE

    Oct-1 Mediates ACTH-Induced Proliferation of Vascular Smooth Muscle Cells

    Qian Xiao1, Xia Tang1, Yuanxiu Chen1, Han Bao1, Lizhi Gao1,2, Xiaobo Gong3,*, Ping Zhang1,4,*
    Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 199-210, 2019, DOI:10.32604/mcb.2019.07107
    Abstract Adrenocorticotrophic hormone (ACTH), a 39-amino acid peptide hormone, has been reported in the appreciation of the proliferation of vascular smooth muscle cells (VSMCs), however, the mechanism in molecular scale supporting the appreciation remains to be elucidated. In this study, we observed that the protein expression levels of ACTH at 24 h after exposure to 15% cyclic stretch were significantly higher than that after 5% cyclic stretch. When VSMCs were treated with 1000 nM ACTH directly, Oct-1 and lamin B1 expression were both up-regulated associating with each other, and the presence of Oct-1 was found shuttling between the cytosol and nucleus.… More >

  • Open Access

    ARTICLE

    Fast Force Loading Disrupts Molecular Binding Stability in Human and Mouse Cell Adhesions

    Yunfeng Chen1,2,3,†,*, Jiexi Liao4,†, Zhou Yuan1, Kaitao Li4, Baoyu Liu4, Lining Arnold Ju4,5,6, Cheng Zhu1,2,4,*
    Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 211-223, 2019, DOI:10.32604/mcb.2019.07267
    Abstract Force plays critical roles in cell adhesion and mechano-signaling, partially by regulating the dissociation rate, i.e., off-rate, of receptor-ligand bonds. However, the mechanism of such regulation still remains elusive. As a controversial topic of the field, when measuring the “off-rate vs. force” relation of the same molecular system, different dynamic force spectroscopy (DFS) assays (namely, force-clamp and force-ramp assays) often yield contradictive results. Such discrepancies hurdled our further understanding of molecular binding, and casted doubt on the existing theoretical models. In this work, we used a live-cell DFS technique, biomembrane force probe, to measure the single-bond dissociation in three receptor-ligand… More >

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