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Jie Wu^∗,†, Quan Long^‡, Shixiong Xu^*, Anwar R. Padhani^§, Yuping Jiang^¶
Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 217-228, 2008, DOI:10.3970/mcb.2008.005.217
Abstract In this paper, a 3D mathematical model of tumour angiogenesis is developed, to generate a functional tumour vasculature for blood microcirculation. The model follows that of Anderson and Chaplain (1998) ^[1] with three exceptions: (a) extending the model from 2D to 3D, one arteriole and one venule is induced as two parent vessels to form an intact circulation network for blood flow; (b) generating networks able to penetrate into the tumour interior rather than the exterior only; (c) considering branching generations with different diameters, based on which three groups of vessels, such as arterioles, venules and… More >

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Abhijit Sinha Roy^*, Lloyd H. Back^†, Rupak K. Banerjee^‡
Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 229-246, 2008, DOI:10.3970/mcb.2008.005.229
Abstract The in vivo and ex vivo compliance of arteries are expected to be closely related and estimated. Fluid-structure interaction analysis can assess the agreement between the two compliances. To evaluate this hypothesis, a pulsatile fluid-structure interaction analysis of blood flow in femoral artery of a dog was conducted using: (1) measured in vivo mean pressure (72.5 mmHg), mean pressure drop (0.59 mmHg), mean velocity (15.1 cm/sec); and (2) ex vivo measurements of non -- linear elastic properties of femoral artery. Additional analyses were conducted for physiological pressures (104.1 and 140.7 mmHg) and blood flow using a characteristic linear pressure More >

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1167

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Colin K. Choi^*, Brian P. Helmke^∗,†
Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 247-258, 2008, DOI:10.3970/mcb.2008.005.247
Abstract Hemodynamic shear stress guides a variety of endothelial phenotype characteristics, including cell morphology, cytoskeletal structure, and gene expression profile. The sensing and processing of extracellular fluid forces may be mediated by mechanotransmission through the actin cytoskeleton network to intracellular locations of signal initiation. In this study, we identify rapid actin-mediated morphological changes in living subconfluent and confluent bovine aortic endothelial cells (ECs) in response to onset of unidirectional steady fluid shear stress (15 dyn/cm²). After flow onset, subconfluent cells exhibited dynamic edge activity in lamellipodia and small ruffles in the downstream and side directions for the… More >

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1131

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Chun Yang^∗,†, Dalin Tang^∗,‡, Shunichi Kobayashi^§, Jie Zheng^¶, Pamela K. Woodard^§, Zhongzhao Teng^*, Richard Bach^||, David N. Ku^∗∗
Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 259-274, 2008, DOI:10.3970/mcb.2008.005.259
Abstract Many acute cardiovascular syndromes such as heart attack and stroke are caused by atherosclerotic plaque ruptures which often happen without warning. MRI-based models with fluid-structure interactions (FSI) have been introduced to perform flow and stress/strain analysis for atherosclerotic plaques and identify possible mechanical and morphological indices for accurate plaque vulnerability assessment. In this paper, cyclic bending was added to 3D FSI coronary plaque models for more accurate mechanical predictions. Curvature variation was prescribed using the data of a human left anterior descending (LAD) coronary artery. Five computational models were constructed based on ex vivo MRI… More >

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1207

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Chen X.Y.^∗,†, Liu Y.^2,‡, Fu B.M.^§, Fan J.T.^¶, Yang J.M.¹
Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 275-284, 2008, DOI:10.3970/mcb.2008.005.275
Abstract Surface glycocalyx, as a barrier to material exchange between circulating blood and body tissues, can be treated as a periodic square array of cylindrical fibers. Previous study treated the glycocalyx as porous media and simulated by continuum theory. However, it has recently been found that a relatively hexagonal fibre-matrix structure may be responsible for the ultrafiltration properties of microvascular walls. The fibre-matrix is an underlaying three-dimensional meshwork with a fibre diameter of 10$\sim$12 nm and characteristic spacing of about 20 nm. The porous medium model does not consider the particle size, when the particle size… More >

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