Home / Journals / MCB / Vol.12, No.4, 2015
Table of Content
  • Open Access

    ARTICLE

    A Coupled Mathematical Model of Cell Migration, Vessel Cooption and Tumour Microenvironment during the Initiation of Micrometastases

    Yan Cai1,2,3, Jie Wu4, Zhiyong Li1,2
    Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 231-248, 2015, DOI:10.3970/mcb.2015.012.231
    Abstract We propose a coupled mathematical model for the detailed quantitative analyses of initial microtumour and micrometastases formation by including cancer cell migration, host vessel cooption and changes in microenvironment. Migrating cells are included as a new phenotype to describe the migration behaviour of malignant tumour cells. Migration probability of a migrating cell is assumed to be influenced by local chemical microenvironment. Pre-existing vessel cooption and remodelling are introduced according to the local haemodynamical microenvironment, such as interstitial pressure and vessel wall permeability. After the tumour cells and tumour vessels distribution are updated, the chemical substances are coupled calculated with the… More >

  • Open Access

    ARTICLE

    Enhanced External Counterpulsation Treatment May Intervene The Advanced Atherosclerotic Plaque Progression by Inducing The Variations of Mechanical Factors: A 3D FSI Study Based on in vivo Animal Experiment

    Jianhang Du1,2,3, Liang Wang4
    Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 249-263, 2015, DOI:10.3970/mcb.2015.012.249
    Abstract Growing evidences suggest that long-term enhanced external counterpulsation (EECP) treatment can inhibit the initiation of atherosclerotic lesion by improving the hemodynamic environment in aortas. However, whether this kind procedure will intervene the progression of advanced atherosclerotic plaque remains elusive and causes great concern in its clinical application presently. In the current paper, a pilot study combining animal experiment and numerical simulation was conducted to investigate the acute mechanical stress variations during EECP intervention, and then to assess the possible chronic effects. An experimentally induced hypercholesterolemic porcine model was developed and the basic hemodynamic measurement was performed in vivo before and… More >

  • Open Access

    ARTICLE

    Design of Orthopedic Plates and Its Modification Based on Feature

    He Kunjin1,2, Zou Zeyu1, Zhang Rongli1
    Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 265-286, 2015, DOI:10.32604/mcb.2015.012.263
    Abstract To quickly construct the orthopedic plates and to conveniently edit it, a novel method for designing the plates is put forward based on feature idea and parameterization. Firstly, attached to the existing or repaired bone model, the region of interest (ROI) is selected as the abutted surface of orthopedic plate, and the ROI is reconstructed to form a CAD surface. Secondly, the CAD surface is to be defined as a surface feature (SF) and then some semantic parameters are configured for it. Lastly, the plate body is constructed through thickening, and some higher parameters are defined for it so as… More >

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