Home / Journals / MCB / Vol.14, No.1, 2017
Table of Content
  • Open Access

    ARTICLE

    Optimum En-Masse Retraction of Six Maxillary Anterior Teeth in Lingual Orthodontics: a Numerical Investigation with 3-Dimensional Finite Element Analysis

    Abhishek M. Thote1,*, Rashmi V. Uddanwadiker1, Krishna Sharma2, Sunita Shrivastava2
    Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 1-17, 2017, DOI:10.3970/mcb.2017.014.001
    Abstract The objective of this study was to devise an optimum force system to achieve en-masse retraction of six maxillary anterior teeth in lingual orthodontics (LiO). First, the set of equations was developed based on the mathematical computation to estimate optimum parameters of force system. Then, the computer software based on this mathematical computation was developed for the ease of estimation of force system. The verification of force system obtained with computer software was accomplished by three-dimensional finite element analysis (FEA). In FEA, it was clear that the desired en-masse retraction of six maxillary anterior teeth in LiO was achieved as… More >

  • Open Access

    ARTICLE

    Anatomical Variations in Circle of Willis and Intracranial Aneurysm Formation

    Zhen Liu1, Yan Cai1, Guo-Zhong Chen2, Guang-Ming Lu, Zhi-Yong Li1,3,*
    Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 19-31, 2017, DOI:10.3970/mcb.2017.014.019
    Abstract Background: Intracranial aneurysm (IA) can be commonly found in the circle of Willis (CoW), and a higher morbidity of IA is found to be associated with a higher percentage of an incomplete CoW. Hemodynamic factors are believed to play an important role in aneurysm formation. However, how the anatomical variations in CoW lead to hemodynamic difference and what hemodynamic parameters play important roles in aneurysm formation have not been quantified and assessed. Methods and Results: Thirty patients were included and based one computed tomography angiography, they were divided into three groups (10 patients per group): a normal group (normal CoW… More >

  • Open Access

    ARTICLE

    Amentoflavone Suppresses Cell Growth and Invasion in Renal Carcinoma Cells by Activating PPARγ

    Kun Fan1,2, Xiaofu Qiu2, Yu Fu2, Kangjian Lin, Huanhui Li2, Guosheng Yang *,1,2
    Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 33-45, 2017, DOI:10.3970/mcb.2017.014.035
    Abstract This study intends to investigate the role of amentoflavone(AF) in human clear-cell renal cell carcinoma (ccRCC) and to elucidate underlying molecular mechanisms. Materials and Methods: Human RCC cell lines Caki-1 and 786-O were used in this study. Cell proliferation, apoptosis, cell cycle distribution and invasion assays were conducted to analyze the effect of AF against ccRCC in vitro. Xenograft model and pulmonary metastasis animal model were established to evaluate the vivo therapeutic efficacy and against pulmonary metastasis ability of AF, respectively. Results: Our findings revealed that AF selectively suppressed tumor cell proliferation in a dose- and time-dependent manner. Treatment with… More >

  • Open Access

    ARTICLE

    3D Numerical Simulation of Effect of Antiangiogenic Factor Angiostatin on Blood Flow and Interstitial Fluid Pressure in the Metastatic Tumor

    Gaiping Zhao1, Feiyi Xia1, Eryun Chen2, Xiaoli Yu3, Zhaozhi Yang3,*
    Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 47-57, 2017, DOI:10.3970/mcb.2017.014.049
    Abstract Metastatic tumor blood perfusion and interstitial fluid transport based on 3D microvasculature response to inhibitory effect of angiostatin are investigated in this paper. 3D blood flow、interstitial fluid transport and transvascular flow are described by the extended Poiseuille’s, Darcy’s and Starling’s law, respectively. Numerical solutions reveal that angiostatin can promote improved blood perfusion and decrease elevated interstitial fluid pressure within the metastatic tumor microenvironment. Moreover, angiostatin can increase interstitial convection within the tumor and result in more efficient drug delivery and penetration within the metastatic tumor, which suits well with the experimental observations. Together, our results may provide therapeutic implications for… More >

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