Home / Journals / MCB / Vol.9, No.4, 2012
Table of Content
  • Open Access

    ARTICLE

    Partial Contact Indentation Tonometry for Measurement of Corneal Properties-Independent Intraocular Pressure

    Match W L Ko, Leo K K Leung, David C C Lam∗,†
    Molecular & Cellular Biomechanics, Vol.9, No.4, pp. 251-268, 2012, DOI:10.3970/mcb.2012.009.251
    Abstract Inter-individual differences in corneal properties are ignored in existing methods for measuring intraocular pressure IOP, a primary parameter used in screening and monitoring of glaucoma. The differences in the corneal stiffness between individuals can be more than double and this difference would lead to IOP measurement errors up to 10 mmHg. In this study, an instrumented partial-contact indentation measurement and analysis method that can account for inter-individual corneal difference in stiffness is developed. The method was tested on 12 porcine eyes ex vivo and 7 rabbit eyes in vivo, and the results were compared to the controlled IOPs to determine… More >

  • Open Access

    ARTICLE

    Stochastic Simulation of Human Pulmonary Blood Flow and Transit Time Frequency Distribution Based on Anatomic and Elasticity Data

    Wei Huang, Jun Shi, R. T. Yen†,‡
    Molecular & Cellular Biomechanics, Vol.9, No.4, pp. 269-284, 2012, DOI:10.3970/mcb.2012.009.269
    Abstract The objective of our study was to develop a computing program for computing the transit time frequency distributions of red blood cell in human pulmonary circulation, based on our anatomic and elasticity data of blood vessels in human lung. A stochastic simulation model was introduced to simulate blood flow in human pulmonary circulation. In the stochastic simulation model, the connectivity data of pulmonary blood vessels in human lung was converted into a probability matrix. Based on this model, the transit time of red blood cell in human pulmonary circulation and the output blood pressure were studied. Additionally, the stochastic simulation… More >

  • Open Access

    ARTICLE

    Design of the Optocoupler Applied to Medical Lighting Systems

    Xibin Yang*, Rui Li†,‡, Jianfeng Zhu*, Daxi Xiong*
    Molecular & Cellular Biomechanics, Vol.9, No.4, pp. 285-294, 2012, DOI:10.3970/mcb.2012.009.285
    Abstract A new type of optocoupler applied to medical lighting system is proposed, and the principle, Etendue and design process is introduced. With the help of Tracrpro, modeling and simulation of the optocoupler is conducted and the parameters are optimized. Analysis of factors affecting the energy coupling efficiency is done. With a view towards the development of Ultra High Brightness Light Emitting Diodes (UHB-LEDs), which play an important role a new sources of lighting in various biomedical devices, including those used in diagnosis and treatment, a series of simulations are executed and a variety of solutions are achieved. According to simulation… More >

  • Open Access

    ARTICLE

    Effect of Danshen on the Zero-Stress State of Rat's Abdominal Aorta

    Hui Han, David C. C. Lam, Wei Huang†,‡
    Molecular & Cellular Biomechanics, Vol.9, No.4, pp. 295-308, 2012, DOI:10.3970/mcb.2012.009.295
    Abstract The objective of our study was to study the effect of danshen, a Chinese herbal medicine known to prevent hypertension, on the zero-stress state of rat's abdominal aorta. The zero-stress state of a blood vessel represents the release of residual stress on the vessel wall, and is the basic configuration of blood vessel affected solely by intrinsic parameters. At the in vivo state, the rat's abdominal aorta was subjected to blood pressure and flow and longitudinal stress. After dissecting from the abdominal aorta, the aortic specimens were cut into small rings at no-load state, in which the internal pressure, external… More >

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