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Stochastic Simulation of Human Pulmonary Blood Flow and Transit Time Frequency Distribution Based on Anatomic and Elasticity Data

Wei Huang, Jun Shi, R. T. Yen†,‡
Dept. of Mechanical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Dept. of Biomedical Engineering, University of Memphis, Memphis, TN 38152
Correspondent author. E-mail: myen@memphis.edu.

Molecular & Cellular Biomechanics 2012, 9(4), 269-284. https://doi.org/10.3970/mcb.2012.009.269

Abstract

The objective of our study was to develop a computing program for computing the transit time frequency distributions of red blood cell in human pulmonary circulation, based on our anatomic and elasticity data of blood vessels in human lung. A stochastic simulation model was introduced to simulate blood flow in human pulmonary circulation. In the stochastic simulation model, the connectivity data of pulmonary blood vessels in human lung was converted into a probability matrix. Based on this model, the transit time of red blood cell in human pulmonary circulation and the output blood pressure were studied. Additionally, the stochastic simulation model can be used to predict the changes of blood flow in human pulmonary circulation with the advantage of the lower computing cost and the higher flexibility. In conclusion, a stochastic simulation approach was introduced to simulate the blood flow in the hierarchical structure of a pulmonary circulation system, and to calculate the transit time distributions and the blood pressure outputs.

Keywords

capillary sheet, connectivity matrix, Diameter-Defined Strahler System, steady blood flow, transit time frequency distribution.

Cite This Article

Huang, W., Shi, J., Yen, R. T. (2012). Stochastic Simulation of Human Pulmonary Blood Flow and Transit Time Frequency Distribution Based on Anatomic and Elasticity Data. Molecular & Cellular Biomechanics, 9(4), 269–284.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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