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Journal Overview

Molecular & Cellular Biomechanics

ISSN: 1556-5297 (Print)

ISSN: 1556-5300 (Online)

Aims & Scope

The field of biomechanics concerns with motion, deformation, and forces in biological systems. With the explosive progress in molecular biology, genomic engineering, bioimaging, and nanotechnology, there will be an ever-increasing generation of knowledge and information concerning the mechanobiology of genes, proteins, cells, tissues, and organs. Such information will bring new diagnostic tools, new therapeutic approaches, and new knowledge on ourselves and our interactions with our environment. It becomes apparent that biomechanics focusing on molecules, cells as well as tissues and organs is an important aspect of modern biomedical sciences. The aims of this journal are to facilitate the studies of the mechanics of biomolecules (including proteins, genes, cytoskeletons, etc.), cells (and their interactions with extracellular matrix), tissues and organs, the development of relevant advanced mathematical methods, and the discovery of biological secrets. As science concerns only with relative truth, we seek ideas that are state-of-the-art, which may be controversial, but stimulate and promote new ideas, new techniques, and new applications. This journal will encourage the exchange of ideas that may be seminal, or hold promise to stimulate others to new findings.
This journal is an indispensable reading and publishing area for all scientists, researchers, engineers, university and professional teachers, industrialists, and people in business interested in inventing, developing, implementing, commercializing, and using processes and products based totally or partly on molecular and cellular biomechanics.

The scope of the journal is thus broad-based, and includes:

Mechanical Behaviors of Biomolecules: Studies of how mechanical forces and deformation affect the conformation, binding/reaction, and transport of biomolecules. Studies of how the structural rigidity of DNA, RNA and proteins under stretching, twisting, bending and shearing affects DNA condensation, gene replication and transcription, DNA-protein/RNA-protein interactions, protein function, protein folding, protein-protein and receptor-ligand interactions. Studies of how mechanobiochemistry couples in biomolecular motors and iron channel flows. Studies of how mechanics influences subcellular structures and protein assemblies/complexes.

Mechanical Behaviors of Cells, Tissues and Organs: Studies of how cells sense mechanical forces or deformations, and transduce them into biological responses. Specifically, studies of how mechanical forces alter cell growth, differentiation, movement, signal transduction, protein secretion and transport, gene expression and regulation. Studies of how cells, tissues, and organs behave, including mixture theories, viscoelastic properties, cell and tissue growth, spreading, rounding, crawling, cell adhesion, cell cytoskeleton dynamics, cell-cell and cell-ECM interactions.

Mechanics in Chemistry and Biology: Studies of how mechanical stimulation affects chemical potentials and cell morphology to activation of signaling cascades and changes in cell phenotype. Studies of how mechanical force is transduced into a biochemical signal, how the cell changes its behavior or properties in response to external or internal stresses causing conformational changes in intracellular binding affinity, cell proliferation, apoptosis and migration, and wound healing. Studies of how mechanics and chemistry of single molecules forms the signal transduction pathways, produces mechanical signal sensation and transduction, with particular attention to their macroscopic manifestation in the cell properties, cytoskeleton rheology and tissue remodeling.

Multiscale Computational Tools: Development of simulation models and numerical methods for the analysis, modeling, and prediction of the biomechanical behaviors and function of single cells (and their extracellular matrix) and biomolecules. Methodologies include Molecular and Langevin dynamics of biomolecules and Mesoscopic modeling techniques, multi-spatial and-time-scale modeling methodologies, and seamless coupling of nano-micro-macro computational models.

Experimental Biomechanics Methods: Development of experimental techniques to study the mechanical behavior of cells including local probes to deform a portion of the cell, mechanical deformation of a single cell, and simultaneous mechanical stressing of a population of cells. Methods for single-molecule biomechanics studies include attaching, positioning and manipulating of single molecules, imaging and measuring deformation, and applying simple or combined loads.

Publication Frequency



The journal is owned by Tech Science Press.


Open Access

All articles published will be Gold open access under the terms and conditions of the Creative Commons Attribution License 4.0 (CC-BY 4.0), and are made freely and permanently accessible online from the date of publication. For further information, please refer to the Open Access Policy.


All journals published by TSP are archived in Portico, which provides permanent digital archiving for scholarly journals.

Ethics Statement

MCB follows the standards of ICMJE. TSP takes the responsibility to enforce a rigorous peer-review together with strict ethical policies and standards to ensure adding the highest quality scientific works to the field of scholarly publication. TSP takes such publishing ethics issues very seriously on every level. Our staff are trained to identify and report any irregularities. Our editors proceed with a zero tolerance policy, to enforce COPE’s Core Practices and Guidelines and swiftly handle complex cases of plagiarism, data falsification, authorship credit, and the like.

Last updated: December 15, 2021

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