Home / Journals / MCB / Vol.16, No.1, 2019
Table of Content
  • Open Access

    ARTICLE

    Mitochondrial Remodeling in Endothelial Cells under Cyclic Stretch is Independent of Drp1 Activation

    Megumi Baba1, Aya Shinmura1, Shigeru Tada1, Taku Amo2, Akira Tsukamoto1,*
    Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 1-12, 2019, DOI:10.32604/mcb.2019.05199
    Abstract Mitochondria in endothelial cells remodel morphologically when supraphysiological cyclic stretch is exerted on the cells. During remodeling, mitochondria become shorter, but how they do so remains elusive. Drp1 is a regulator of mitochondrial morphologies. It shortens mitochondria by shifting the balance from mitochondrial fusion to fission. In this study, we hypothesized that Drp1 activation is involved in mitochondrial remodeling under supraphysiological cyclic stretch. To verify the involvement of Drp1, its activation was first quantified with Western blotting, but Drp1 was not significantly activated in endothelial cells under supraphysiological cyclic stretch. Next, Drp1 activation was inhibited with Mdivi-1, but this did… More >

  • Open Access

    ARTICLE

    Characterizing the Mechanical Variations of Human Femoropopliteal Artery During Aging Process

    Shaoxiong Yang1, Yingxin Qi2, Zonglai Jiang2, Xiaobo Gong1,*
    Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 13-26, 2019, DOI:10.32604/mcb.2019.06096
    Abstract Vascular diseases during aging process are closely correlated to the age-related changes of mechanical stimuli for resident cells. Characterizing the variations of mechanical environments in vessel walls with advancing age is crucial for a better understanding of vascular remodeling and pathological changes. In this study, the mechanical stress, strain, and wall stiffness of the femoropopliteal arteries (FPAs) were compared among four different age groups from adolescent to young, middle-aged, and aged subjects. The material parameters and geometries adopted in the FPA models were obtained from published experimental results. It is found that high mechanical stress appears at different layers in… More >

  • Open Access

    ARTICLE

    DSA-Based Quantitative Assessment of Cerebral Hypoperfusion in Patients with Asymmetric Carotid Stenosis

    Xu Zhang1,‡, Jie Gao2,‡, Xinke Yao1, Zhengze Dai3,4, Gelin Xu2,*, Yan Cai1,*, Zhiyong Li1,5,*
    Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 27-39, 2019, DOI:10.32604/mcb.2019.06140
    Abstract Digital subtraction angiography (DSA) is often used to evaluate the morphological and pathological changes of cerebral arteries in clinical practice. This study aims to explore the possibility of assessing cerebral hypoperfusion with DSA in patients with carotid stenosis. Thirty patients with a mild to severe stenosis on one side, and a mild stenosis on the other side of the carotid artery were recruited. Frontal, parietal, temporal and occipital lobes were chosen as regions of interest for measuring the quantitative perfusion parameters from their time-density curves (TDCs) of DSA images. The perfusion parameters were compared between the two hemispheres by using… More >

  • Open Access

    ARTICLE

    Epigenetic Modulations Induction Using DSCR1 Ectopic Expression in Breast Cancer Cells

    Zahra Niki Boroujeni1, Atefeh Shirkav1, Seyed Ahmad Aleyasin1,*
    Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 41-58, 2019, DOI:10.32604/mcb.2019.04366
    Abstract Today, prognosis, diagnosis and treatment of cancers are progressing with non-invasive methods, including investigation and modification of the DNA methylation profile in cancer cells. One of the effective factors in regulating gene expression in mammals is DNA methylation. Methylation alterations of genes by external factors can change the expression of genes and inhibit the cancer. In the present study, we investigated the effect of Down syndrome critical region 1 gene (DSCR1) ectopic expression on the methylation status of the BCL-XL, ITGA6, TCF3, RASSF1A, DOK7, VIM and CXCR4 genes in breast cancer cell lines. The effect of DSCR1 ectopic expression on… More >

  • Open Access

    ARTICLE

    Experimental Study of Aqueous Humor Flow in a Transparent Anterior Segment Phantom by Using PIV Technique

    Wenjia Wang1, 2, Xiuqing Qian1, 2, Qi Li1, 2, Gong Zhang1, 2, Huangxuan Zhao1, 2, Tan Li1, 2, Yang Yu1, 2, Hongfang Song1, 2, *, Zhicheng Liu1, 2, *
    Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 59-74, 2019, DOI:10.32604/mcb.2019.06393
    Abstract Pupillary block is considered as an important cause of primary angle-closure glaucoma (PACG). In order to investigate the effect of pupillary block on the hydrodynamics of aqueous humor (AH) in anterior chamber (AC) and potential risks, a 3D printed eye model was developed to mimic the AH flow driven by fluid generation, the differential pressure between AC and posterior chambers (PC) and pupillary block. Particle image velocimetry technology was applied to visualize flow distribution. The results demonstrated obvious differences in AH flow with and without pupillary block. Under the normal condition (without pupillary block), the flow filed of AH was… More >

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