Home / Journals / MCB / Vol.7, No.4, 2010
Table of Content
  • Open Access

    ARTICLE

    Computer Simulations of Atherosclerotic Plaque Growth in Coronary Arteries

    Biyue Liu, Dalin Tang
    Molecular & Cellular Biomechanics, Vol.7, No.4, pp. 193-202, 2010, DOI:10.3970/mcb.2010.007.193
    Abstract A three dimensional mathematical model with a linear plaque growth function was developed to investigate the geometrical adaptation of atherosclerotic plaques in coronary arteries and study the influences of flow wall shear stress (WSS), blood viscosity and the inlet flow rate on the growth of atherosclerotic plaques using computational plaque growth simulations. The simulation results indicated that the plaque wall thickness at the neck of the stenosis increased at a decreasing rate in the atherosclerosis progression. The simulation results also showed a strong dependence of the plaque wall thickness increase on the blood viscosity and the inlet flow rate. The… More >

  • Open Access

    ARTICLE

    Simulation and Modeling of Laser-Tissue Interactions Based on a Liposome-Dye System

    F.E. Mensah∗,†, R. Sridhar, P. Misra
    Molecular & Cellular Biomechanics, Vol.7, No.4, pp. 203-212, 2010, DOI:10.3970/mcb.2010.007.203
    Abstract This work presents an overview of the use of liposomes for targeted delivery of photosensitizers to tumors for Photodynamic Therapy (PDT). It assesses the results of a quantitative model to explain the interaction of short-pulsed lasers (in the nanosecond and picosecond domains) with a liposome-dye complex in terms of a localized photo-induced thermal mechanism. Incorporation of an organic dye (sulforhodamine) within lipid vesicles has been investigated in conjunction with the effect of laser irradiation on the integrity of the liposome-dye complex. The variation of the absorption coefficient as a function of wavelength for dye-encapsulated liposomes before and after laser-induced release… More >

  • Open Access

    ARTICLE

    Dynamic Effects on the Formation and Rupture of Aneurysms

    J.S. Ren*
    Molecular & Cellular Biomechanics, Vol.7, No.4, pp. 213-224, 2010, DOI:10.3970/mcb.2010.007.213
    Abstract Dynamic analysis of an axially stretched arterial wall with collagen fibers distributed in two preferred directions under a suddenly applied constant internal pressure along with the possibility of the formation and rupture of aneurysm are examined within the framework of nonlinear dynamics. A two layer tube model with the fiber-reinforced composite-based incompressible anisotropic hyper-elastic material is employed to model the mechanical behavior of the arterial wall. The maximum amplitudes and the phase diagrams are given by numerical computation of the differential relation. It is shown that the arterial wall undergoes nonlinear periodic oscillation and no aneurysms are formed under the… More >

  • Open Access

    ARTICLE

    Cancer Cell(s) Cycle Sequencing Reveals Universal Mechanisms of Apoptosis

    R. M. Ardito Marretta*, F. Ales
    Molecular & Cellular Biomechanics, Vol.7, No.4, pp. 225-266, 2010, DOI:10.3970/mcb.2010.007.225
    Abstract In this paper, cell cycle in higher eukaryotes and their molecular networks signals both inG1/SandG2/Mtransitions are replicatedin silico. Biochemical kinetics, converted into a set of differential equations, and system control theory are employed to design multi-nested digital layers to simulate protein-to-protein activation and inhibition for cell cycle dynamics in the presence of damaged genomes. Sequencing and controlling the digital process of four micro-scale species networks (p53/Mdm2/DNA damage, p21mRNA/cyclin-CDK complex, CDK/CDC25/wee1/ SKP2/APC/CKI and apoptosis target genes system) not only allows the comprehension of the mechanisms of these molecule interactions but paves the way for unraveling the participants and their by-products, until… More >

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