Home / Journals / MCB / Vol.12, No.2, 2015
Table of Content
  • Open Access

    ARTICLE

    3D Fluid-Structure Interaction Canine Heart Model with Patch to Quantify Mechanical Conditions for Optimal Myocardium Stem Cell Growth and Tissue Regeneration

    Heng Zuo*, Dalin Tang*,†,‡, Chun Yang*,§, Glenn Gaudette, Kristen L. Billiar, Pedro J. del NidokII
    Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 67-85, 2015, DOI:10.3970/mcb.2015.012.067
    Abstract Right ventricular (RV) dysfunction is a common cause of heart failure in patients with congenital heart defects and often leads to impaired functional capacity and premature death. Myocardial tissue regeneration techniques are being developed for the potential that viable myocardium may be regenerated to replace scar tissues in the heart or used as patch material in heart surgery. 3D computational RV/LV/Patch models with fluid-structure interactions (FSI) were constructed based on data from a healthy dog heart to obtain local fluid dynamics and structural stress/strain information and identify optimal conditions under which tissue regeneration techniques could achieve best outcome. RV/LV/Patch geometry… More >

  • Open Access

    ARTICLE

    Numerical Evaluation of Trabecular Bone Alterations: A Cell Method Application

    Francesca Cosmi*
    Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 87-105, 2015, DOI:10.3970/mcb.2015.012.087
    Abstract Bone tissue is a complex multi-scale material and its morphological and functional characteristics are influenced during one’s life by constant changes, physiological and pathological. A recent technique can classify the mechanical response of trabecular bone by simulating the application of loads with a Cell Method model derived from plane radiographic images of the proximal epiphyses in the patient’s hand fingers, thus complementing the individual assessment with a low cost exam. The mesoscale pathological modifications (i.e. due to osteoporosis) can be detected and quantified, despite the simplification due to the use of radiograms. In this work, this approach is validated using… More >

  • Open Access

    ARTICLE

    Using 2D In Vivo IVUS-Based Models for Human Coronary Plaque Progression Analysis and Comparison with 3D Fluid-Structure Interaction Models: A Multi-Patient Study

    Hongjian Wang*, Jie Zheng, LiangWang, Akiko Maehara§, Chun YangII, David Muccigrosso, Richard BachkII, Jian Zhu**, Gary S. Mintz§, Dalin Tang*,‡,††
    Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 107-122, 2015, DOI:10.3970/mcb.2015.012.107
    Abstract Computational modeling has been used extensively in cardiovascular and biological research, providing valuable information. However, 3D vulnerable plaque model construction with complex geometrical features and multicomponents is often very time consuming and not practical for clinical implementation. This paper investigated if 2D atherosclerotic plaque models could be used to replace 3D models to perform correlation analysis and achieve similar results. In vivo intravascular ultrasound (IVUS) coronary plaque data were acquired from a patient follow-up study to construct 2D structure-only and 3D FSI models to obtain plaque wall stress (PWS) and strain (PWSn) data. One hundred and twenty-seven (127) matched IVUS… More >

  • Open Access

    ARTICLE

    Quick Construction of Femoral Model Using Surface Feature Parameterization

    Xiaozhong Chen∗,†, Kunjin He, Zhengming Chen∗,‡, Wei Xiang§
    Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 123-146, 2015, DOI:10.3970/mcb.2015.012.123
    Abstract To facilitate the modifying of femoral surface model, by dividing the femoral mesh into surface feature units bearing medical significance based on surface feature technology, a new approach of constructing femoral models using surface feature technology is proposed. Firstly, considering of femoral anatomy, the femoral triangle mesh model generated from the averaged point-clouds is divided into several specific regions, which are called feature regions; Secondly, feature parameters are defined and the constraints among them are set up, and feature surfaces are created by skinning the contours; Finally, the adjacent feature surfaces are connected by transition surfaces, and the parametric CAD… More >

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