Home / Journals / MCB / Vol.8, No.1, 2011
Table of Content
  • Open Access

    ARTICLE

    Influence of Arterial Wall Compliance on the Pressure Drop across Coronary Artery Stenoses under Hyperemic Flow Condition

    Bhaskar Chandra Konala, Ashish Das, Rupak K Banerjee∗,†
    Molecular & Cellular Biomechanics, Vol.8, No.1, pp. 1-20, 2011, DOI:10.3970/mcb.2011.008.001
    Abstract Hemodynamic endpoints such as flow and pressure drop are often measured during angioplasty procedures to determine the functional severity of a coronary artery stenosis. There is a lack of knowledge regarding the influence of compliance of the arterial wall-stenosis on the pressure drop under hyperemic flows across coronary lesions. This study evaluates the influence in flow and pressure drop caused by variation in arterial-stenosis compliance for a wide range of stenosis severities. The flow and pressure drop were evaluated for three different severities of stenosis and tested for limiting scenarios of compliant models. The Mooney-Rivlin model defined the non-linear material… More >

  • Open Access

    ARTICLE

    Comparison of Hemodynamic Endpoints between Normal Subject and Tetralogy Patient Using Womersley Velocity Profile and MR Based Flow Measurements

    Ashish Das, William M. Gottliebson†,‡, Madhura Karve, Rupak Banerjee∗,§,¶
    Molecular & Cellular Biomechanics, Vol.8, No.1, pp. 21-42, 2011, DOI:10.3970/mcb.2011.008.021
    Abstract Right ventricular (RV) enlargement and pulmonary valve insufficiency (PI) are well-known, unavoidable long term sequelae encountered by patients who undergo tetralogy of Fallot (TOF) surgery. Despite their lifelong need for cardiac surveillance and occasional re-intervention, there is a paucity of numerical data characterizing blood flows in their pulmonary arteries (PA). Specifically, although PA regurgitation is well-known to be ubiquitously present in adult repaired TOF (rTOF) patients yet, there have been only limited numerical studies to fully characterize this process. The few studies available have utilized idealized, simplistic geometric models or overly simplistic boundary conditions that fail to account for flow… More >

  • Open Access

    ARTICLE

    Effect of Mechanical Pressure on the Thickness and Collagen Synthesis of Mandibular Cartilage and the Contributions of G Proteins

    Min Zhang, Fa-Ming Chen, Yong-Jin Chen∗,‡, Shun Wu, Xin Lv, Rui-Ni Zhao
    Molecular & Cellular Biomechanics, Vol.8, No.1, pp. 43-60, 2011, DOI:10.3970/mcb.2011.008.043
    Abstract To investigate the role of mechanical pressure on cartilage thickness and type II collagen synthesis, and the role of G protein in that process, in vitro organ culture of mandibular cartilage was adopted in this study. A hydraulic pressure-controlled cellular strain unit was used to apply hydrostatic pressurization to explant cultures. The explants were compressed by different pressure values (0 kPa, 100 kPa, and 300 kPa) after pretreatment with or without a selective and direct antagonist (NF023) for the G proteins. After 4, 8 and 12 h of cell culture under each pressure condition, histological sections of the explants were… More >

  • Open Access

    ARTICLE

    A Study of Frictional Property of the Human Fingertip Using Three-Dimensional Finite Element Analysis

    Hiroaki Yoshida, Mitsunori Tada, Masaaki Mochimaru
    Molecular & Cellular Biomechanics, Vol.8, No.1, pp. 61-72, 2011, DOI:10.3970/mcb.2011.008.061
    Abstract Since the tactile perception detects skin deformation due to the contact of an object, it is important to understand contact mechanics, especially, frictional behavior of the human fingertip. The coefficient of friction is recently modeled as a function of the applied normal load in which case the traditional Coulomb's law does not provide a description for the skin surface. When a surface is a rubber-like material, the frictional behavior follows the frictional law of the rubber-like material. Therefore, we developed a three-dimensional Finite Element model of the fingertip and analyzed frictional behavior based on the frictional law of rubber-like material.… More >

  • Open Access

    ARTICLE

    Influence of non-Newtonian Properties of Blood on the Wall Shear Stress in Human Atherosclerotic Right Coronary Arteries

    Biyue Liu, Dalin Tang
    Molecular & Cellular Biomechanics, Vol.8, No.1, pp. 73-90, 2011, DOI:10.3970/mcb.2011.008.073
    Abstract The objective of this work is to investigate the effect of non-Newtonian properties of blood on the wall shear stress (WSS) in atherosclerotic coronary arteries using both Newtonian and non-Newtonian models. Numerical simulations were performed to examine how the spatial and temporal WSS distributions are influenced by the stenosis size, blood viscosity, and flow rate. The computational results demonstrated that blood viscosity properties had considerable effect on the magnitude of the WSS, especially where disturbed flow was observed. The WSS distribution is highly non-uniform both temporally and spatially, especially in the stenotic region. The maximum WSS occurred at the proximal… More >

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