Home / Journals / MCB / Vol.10, No.4, 2013
Table of Content
  • Open Access

    ARTICLE

    Purmorphamine Promotes Matrix Mineralization and Cytoskeletal Changes in Human Umbilical Cord Mesenchymal Stem Cells

    Syed A Jamal*
    Molecular & Cellular Biomechanics, Vol.10, No.4, pp. 267-273, 2013, DOI:10.3970/mcb.2013.010.267
    Abstract Human Umbilical Cord Mesenchymal Stem Cells (hUCMSCs) were subjected to in vitro osteogenic differentiation using a novel combination of signaling molecules including BMP-2 and purmorphamine. Differentiation outcomes were assessed by calcein staining and by microscopic examination of the cytoskeleton. Calcein staining showed appreciable degree of calcium mineralization in cell culture, and changes in the morphological attributes of differentiating cells were observed vis-a-vis the actin cytoskeleton. Finally, positive calcein staining, altered cytoskeletal profile, and stress fiber formation in treated cells demonstrated, for the first time, a potentially synergistic interplay between BMP-2 and the hedgehog agonist, purmorphamine. This study lends support to… More >

  • Open Access

    ARTICLE

    Deletion of the TPM1 and MDM20 Genes Affect the Mechanical and Structural Properties of Yeast Cells

    Annette Doyle*, Steven R. Crosby, David R. Burton*, Francis Lilley*, Gary Johnston*, Winder B. Perez, Terri G. Kinzy, Mark F. Murphy*,†,§
    Molecular & Cellular Biomechanics, Vol.10, No.4, pp. 275-288, 2013, DOI:10.3970/mcb.2013.010.275
    Abstract Many diseases including cancer are associated with a disorganised cytoskeleton. The process of characterising how cytoskeletal disorganisation affects the mechanical properties of cells offers the potential to develop new drugs and treatment regimes that may exploit mechanical weakness in cells and tissues. This work investigated the role of actin associated proteins, namely tropomyosin 1 (tpm1p) and mitochondrial distribution and morphology protein 20 (mdm20p), on the mechanical and morphological properties of yeast cells. For the first time it was shown that deletion of both the TPM1 and MDM20 genes resulted in a decrease in Young’s modulus when compared to the wild-type… More >

  • Open Access

    ARTICLE

    Thermo-Mechanical Analysis of Restored Molar Tooth using Finite Element Analysis

    R. V. Uddanwadiker*
    Molecular & Cellular Biomechanics, Vol.10, No.4, pp. 289-302, 2013, DOI:10.3970/mcb.2013.010.289
    Abstract The aim of the study is to find most optimum combination of crown material and adhesive to avoid loosening and thereby failure of restored tooth. This study describes the Thermo-Mechanical analysis of restored molar tooth crown for determination of the stress levels due to thermal and mechanical loads on restored molar tooth. The potential use of the 3-D model was demonstrated and analyzed using different materials for crown. Thermal strain, stress and deformation were measured at hot and cold conditions in ANSYS and correlated with analytical calculation and existing experimental data for model validation and optimization. It is concluded that… More >

  • Open Access

    ARTICLE

    Study of Biomechanical Response of Human Hand-Arm to Random Vibrations of Steering Wheel of Tractor

    G. Geethanjali, C. Sujatha
    Molecular & Cellular Biomechanics, Vol.10, No.4, pp. 303-317, 2013, DOI:10.3970/mcb.2013.010.303
    Abstract This paper reports a study on the biomechanical response of a human hand-arm model to random vibrations of the steering wheel of a tractor. An anatomically accurate bone-only hand-arm model from TurboSquidTM was used to obtain a finite element (FE) model to understand the Hand-arm vibration syndrome (HAVS), which is a neurological and vascular disorder caused by exposure of the human hand-arm to prolonged vibrations. Modal analysis has been done to find out the first few natural frequencies and mode shapes of the system. Coupling of degrees of freedom (DOF) had to be done in the FE idealization to do… More >

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