Home / Journals / MCB / Vol.14, No.4, 2017
Table of Content
  • Open Access

    ARTICLE

    Shear Stress and Oxidized LDL Regulates Endothelial Cell Tube Formation through VEGF Signaling

    Bo Ling1,#, Daoxi Lei1,#, Juhui Qiu1, Kang Zhang1, Hao Chen2,*, Yeqi Wang1, Zhiyi Ye1, Guixue Wang*
    Molecular & Cellular Biomechanics, Vol.14, No.4, pp. 197-211, 2017, DOI:10.3970/mcb.2017.014.197
    Abstract Shear stress and oxidized low-density lipoprotein (oxLDL) caused by abnormal blood is critical to angiogenesis for atherosclerosis. However, the mechanism in shear stress or ox-LDL regulated angiogenesis is still not well understood. There is the hypothesis that shear stress or oxLDL regulates angiogenesis through the vascular endothelial growth factor (VEGF) signaling pathway. It is discovered that both high shear stress and low concentration of oxLDL contribute to angiogenesis, which is inhibited once the VEGF or VEGFR expression is knocked down. The expression of p-FAK and p-paxillin is regulated by the VEGF/VEGFR signal axis. VEGFR2, p-FAK, p-paxillin and VEGFR1 are VEGF-responsive… More >

  • Open Access

    ARTICLE

    Impact of Coronary Tortuosity on Coronary Pressure and Wall Shear Stress: an Experimental Study

    Yang Li1, Xiuxian Liu2, Zhiyong Li2,*, Jiayi Tong1, Yi Feng1, Genshan Ma1, Chengxing Shen3, Naifeng Liu1
    Molecular & Cellular Biomechanics, Vol.14, No.4, pp. 213-229, 2017, DOI:10.3970/mcb.2017.014.213
    Abstract Coronary tortuosity is a common angiographic finding, but the hemodynamic significance of coronary tortuosity is largely unknown. The impact of coronary tortuosity on coronary pressure and wall shear stress is still unclear. We addressed this issue in the present experimental study. A distorted tube model connected to heart pumping machine was established to simulate the coronary circulation. The pressure of each point was measured with a coronary pressure guidewire. Influence of tortuosity angle and tortuosity number on local pressure was measured. Wall shear stress was calculated accordingly to the pressure of each point. Pressure distribution in this system was affected… More >

  • Open Access

    ARTICLE

    On the Crack Spreading in Traverse Section of Bovine Bone

    Longjia Li1,2, Tianbao Qian2,3, Fei Hang1, 2, *
    Molecular & Cellular Biomechanics, Vol.14, No.4, pp. 221-234, 2017, DOI:10.3970/mcb.2017.014.221
    Abstract Bone is an important natural hierarchical biomaterial which supports human body and protect organs. Its mechanical property has been researched extensively. In this experimental work, 3D microscope and scanning electron microscope (SEM) were used to research crack expansion on bovine femur cortical bone transverse section. Softwares such as image J and Photoshop were used in image and data analyses. Our results suggested that the interface energy of extending through osteons is smaller than the interface energy of extending along cement lines. Cracks are more likely to extend through osteons. Further investigations are needed to reduce errors and validate our findings. More >

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