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Impact of Coronary Tortuosity on Coronary Pressure and Wall Shear Stress: an Experimental Study

Yang Li1, Xiuxian Liu2, Zhiyong Li2,*, Jiayi Tong1, Yi Feng1, Genshan Ma1, Chengxing Shen3, Naifeng Liu1
Department of Cardiology, Zhongda Hospital, Medical school, Southeast University, Nanjing, China.
School of Biological Science and Medical Engineering, Southeast University, Nanjing, China .
Department of Cardiology, Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China .
* Corresponding Author: Zhiyong Li. Email: .

Molecular & Cellular Biomechanics 2017, 14(4), 213-229. https://doi.org/10.3970/mcb.2017.014.213

Abstract

Coronary tortuosity is a common angiographic finding, but the hemodynamic significance of coronary tortuosity is largely unknown. The impact of coronary tortuosity on coronary pressure and wall shear stress is still unclear. We addressed this issue in the present experimental study. A distorted tube model connected to heart pumping machine was established to simulate the coronary circulation. The pressure of each point was measured with a coronary pressure guidewire. Influence of tortuosity angle and tortuosity number on local pressure was measured. Wall shear stress was calculated accordingly to the pressure of each point. Pressure distribution in this system was affected both by tortuosity angle and tortuosity number. Driving pressure for the coronary tortuosity was positively related with tortuosity number while negatively linked with tortuosity angle. Wall shear stress was higher in proportion to the severity of coronary tortuosity. Coronary tortuosity can lead to more decrease of coronary blood pressure in dependence on the severity of tortuosity, and driving pressure for the coronary tortuosity increased accordingly. Tortuous artery has higher wall shear stress in dependent on the severity of coronary tortuosity, indicated that coronary tortuosity may be a factor for delaying the formation and progression of atherosclerotic plaque.

Keywords

Coronary tortuosity, coronary pressure, wall shear stress.

Cite This Article

Li, Y., Liu, X., Li, Z., Tong, J., Feng, Y. et al. (2017). Impact of Coronary Tortuosity on Coronary Pressure and Wall Shear Stress: an Experimental Study. Molecular & Cellular Biomechanics, 14(4), 213–229.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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