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IVUS-Based Computational Modeling and Planar Biaxial Artery Material Properties for Human Coronary Plaque Vulnerability Assessment


Haofei Liu*, Mingchao Cai*, Chun Yang∗,†, Jie Zheng, Richard Bach§, Mehmet H. Kural, Kristen L. Billiar, David Muccigrosso, Dongsi Lu||, Dalin Tang∗,∗∗

* Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA 01609
School of Mathematical Sciences, Beijing Normal University, Key Laboratory of Mathematics and Complex Systems, Ministry of Education, Beijing, 100875, China
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110 USA
§ Cardiovascular Division, Washington University School of Medicine, Saint Louis, MO 63110, USA
Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609
|| Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA
∗∗ Dalin Tang, Corresponding author, 508-845-1575, dtang@wpi.edu

Molecular & Cellular Biomechanics 2012, 9(1), 77-94. https://doi.org/10.3970/mcb.2012.009.077

Abstract

Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better plaque assessment and rupture predictions. In vivo patient-specific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. A framework is proposed to combine intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling with fluid-structure interactions and anisotropic material properties to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions. Impact of pre-shrink-stretch process, vessel curvature and high blood pressure on stress, strain, flow velocity and flow maximum principal shear stress was investigated.

Keywords

Coronary artery, cardiovascular, fluid-structure interaction, atherosclerotic plaque rupture, IVUS.

Cite This Article

, . (2012). IVUS-Based Computational Modeling and Planar Biaxial Artery Material Properties for Human Coronary Plaque Vulnerability Assessment. Molecular & Cellular Biomechanics, 9(1), 77–94.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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