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3D Numerical Study of Tumor Microenvironmental Flow in Response to Vascular-Disrupting Treatments

Jie Wu∗,†, Yan Cai, Shixiong Xu§, Quan Long, Zurong Ding*, Cheng Dong∗,||

School of Naval Architecture, Ocean and Civil Engineering, MOE Key Laboratory of Hydrodynamics, Shanghai Jiao Tong University, Shanghai, China
Corresponding author. Email:; Phone: +86-021-34204313, +86-13564458476
School of Biological Science and Medical Engineering, Southeast University, China
§ Department of Mechanics and Engineering Science, Fudan University, Shanghai, China
Brunel Institute for Bioengineering, Brunel University, Uxbridge, Middlesex, UK
|| Department of Bioengineering & Department of Engineering Science and Mechanics, The Pennsylvania State University, The Pennsylvania State, USA

Molecular & Cellular Biomechanics 2012, 9(2), 95-126.


The effects of vascular-disrupting treatments on normalization of tumor microvasculature and its microenvironmental flow were investigated, by mathematical modeling and numerical simulation of tumor vascular-disrupting and tumor haemodynamics. Four disrupting approaches were designed according to the abnormal characteristics of tumor microvasculature compared with the normal one. The results predict that the vascular-disrupting therapies could improve tumor microenvironment, eliminate drug barrier and inhibit metastasis of tumor cells to some extent. Disrupting certain types of vessels may get better effects. In this study, the flow condition on the networks with "vascular-disrupting according to flowrate" is the best comparing with the other three groups, and disrupting vessels of lower maturity could effectively enhance fluid transport across vasculature into interstitial space.


Cite This Article

Wu, J., Cai, Y., Xu, S., Long, Q., Ding, Z. et al. (2012). 3D Numerical Study of Tumor Microenvironmental Flow in Response to Vascular-Disrupting Treatments. Molecular & Cellular Biomechanics, 9(2), 95–126.

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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