Open Access
ARTICLE
IL13RA2 promotes progression of infantile haemangioma by activating glycolysis and the Wnt/β-catenin signaling pathway
ZIYONG LIU1,#, TAO MA1,#, JINFANG LI2, WEI REN1,*, ZHIXIN ZHANG1,*
1 Department of Cardiothoracic Surgery, 970th Hospital of the People’s Liberation Army, Weihai, 264209, China
2 Department of Cardiac Ultrasound, Weihai Municipal Hospital, Weihai, 264200, China
* Corresponding Author: WEI REN. Email: 
; ZHIXIN ZHANG. Email: 
Oncology Research https://doi.org/10.32604/or.2024.048315
Received 04 December 2023; Accepted 01 February 2024; Published online 26 March 2024
Abstract
Background:: Interleukin 13 receptor subunit alpha 2 (IL13RA2) plays an essential role in the progression of many cancers. However, the role of IL13RA2 in infantile haemangioma (IH) is still unknown. Materials and Methods:: IL13RA2 expression in IH tissues was analyzed using western blot, qRT-PCR, and immunofluorescence. The role of IL13RA2 in haemangioma-derived endothelial cells (HemECs) was determined following knockdown or overexpression of IL13RA2 using CCK-8, colony formation, apoptosis, wound healing, tubule formation, Transwell, and western blot. Results:: IL13RA2 expression was upregulated in IH tissues. IL13RA2 overexpression promoted proliferation, migration, and invasion of HemECs and induced glycolysis, which was confirmed with a glycolysis inhibitor. Specifically, IL13RA2 interacted with β-catenin and activated the Wnt/β-catenin pathway in HemECs, which were involved in the above-mentioned effects of IL13RA2. Conclusions:: These findings revealed that targeting IL13RA2 is a potential therapeutic approach for IH.
Keywords
Infantile haemangioma; IL13RA2; Glycolysis; Wnt/β-catenin pathway
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