Table of Content

Open Access iconOpen Access

ARTICLE

miRNA-214 Inhibits Cellular Proliferation and Migration in Glioma Cells Targeting Caspase 1 Involved in Pyroptosis

Zhenfeng Jiang*1, Lifen Yao†1, Hongge Ma, Panpan Xu, Zhiyan Li, Mian Guo, Jianhang Chen*, Hongbo Bao§, Shupei Qiao, Yufang Zhao, Jia Shen#, Minwei Zhu*, Carolyn Meyers**, Guizhen Ma††, Chuncheng Xie*, Li Liu*, Haiyang Wang*, Wang Zhang*, Qi Dong, Hong Shen*, Zhiguo Lin*

* Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China
† Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China
‡ Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, P.R. China
§ Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin, P.R. China
¶ Bio-X Center, School of Life Science and Technology, Harbin Institute of Technology, Harbin, P.R. China
# Orthopedic Hospital Research Center, University of California, Los Angeles, CA, USA
** Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
†† Department of Operating Room, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China
1 These authors provided equal contribution to this work as first authors.

Oncology Research 2017, 25(6), 1009-1019. https://doi.org/10.3727/096504016X14813859905646

Abstract

Pyroptosis is a type of proinflammatory programmed cell death mediated by caspase 1 activity and occurs in several types of eukaryotic tumor cells, including gliomas. MicroRNAs (miRNAs), small endogenous noncoding RNAs, have been demonstrated to be advantageous in glioma therapy. However, the question of whether miRNAs regulate pyroptosis in glioma remains unknown. The current study found that caspase 1 expression was substantially increased in both glioma tissues and glioma cell lines, U87 and T98G, while miR-214 expression was significantly downregulated. Luciferase reporter assay recognized caspase 1 as a target gene of miR-214. These findings demonstrate that miR-214 could inhibit cell proliferation and migration through the regulation of pyroptosis intermediated by caspase 1 in glioma U87 and T98G cells and may suggest a novel therapeutic for the intervention of glioma.

Keywords


Cite This Article

APA Style
Jiang, Z., Yao, L., Ma, H., Xu, P., Li, Z. et al. (2017). Mirna-214 inhibits cellular proliferation and migration in glioma cells targeting caspase 1 involved in pyroptosis. Oncology Research, 25(6), 1009-1019. https://doi.org/10.3727/096504016X14813859905646
Vancouver Style
Jiang Z, Yao L, Ma H, Xu P, Li Z, Guo M, et al. Mirna-214 inhibits cellular proliferation and migration in glioma cells targeting caspase 1 involved in pyroptosis. Oncol Res. 2017;25(6):1009-1019 https://doi.org/10.3727/096504016X14813859905646
IEEE Style
Z. Jiang et al., "miRNA-214 Inhibits Cellular Proliferation and Migration in Glioma Cells Targeting Caspase 1 Involved in Pyroptosis," Oncol. Res., vol. 25, no. 6, pp. 1009-1019. 2017. https://doi.org/10.3727/096504016X14813859905646



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 30

    View

  • 28

    Download

  • 0

    Like

Share Link