Table of Content

Open Access iconOpen Access

ARTICLE

Overexpression of Hepatocyte Cell Adhesion Molecule (hepaCAM) Inhibits the Proliferation, Migration, and Invasion in Colorectal Cancer Cells

Hai-tao Geng*, Rui-juan Cao*, Lei Cheng, Chun-yuan Liu

* Department of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong, P.R. China
† Department of General Surgery, Binzhou Medical University Hospital, Binzhou, Shandong, P.R. China

Oncology Research 2017, 25(7), 1039-1046. https://doi.org/10.3727/096504016X14813914187138

Abstract

Hepatocyte cell adhesion molecule (hepaCAM), a new type of CAM, belongs to the immunoglobulin superfamily. Recently, hepaCAM was reported to be implicated in cancer development, and many researchers investigated its biological function in the tumorigenesis of various cancers. However, what kind of role hepaCAM plays in colorectal cancer (CRC) remains unknown. In this study, we found that hepaCAM was downregulated in CRC tissues and cell lines. Overexpression of hepaCAM inhibited CRC cell proliferation, migration, and invasion in vitro. Furthermore, the tumorigenesis assay showed that increased expression of hepaCAM suppressed CRC tumor growth and metastasis in vivo. We also demonstrated that overexpression of hepaCAM reduced the protein expression levels of β-catenin, cyclin D1, and c-Myc, indicating its inhibitory effect on the Wnt/β-catenin signaling pathway. In conclusion, our study results suggest hepaCAM as a promising therapeutic target for CRC and provide a better understanding for the molecular basis of CRC progression.

Keywords


Cite This Article

APA Style
Geng, H., Cao, R., Cheng, L., Liu, C. (2017). Overexpression of hepatocyte cell adhesion molecule (hepacam) inhibits the proliferation, migration, and invasion in colorectal cancer cells. Oncology Research, 25(7), 1039-1046. https://doi.org/10.3727/096504016X14813914187138
Vancouver Style
Geng H, Cao R, Cheng L, Liu C. Overexpression of hepatocyte cell adhesion molecule (hepacam) inhibits the proliferation, migration, and invasion in colorectal cancer cells. Oncol Res. 2017;25(7):1039-1046 https://doi.org/10.3727/096504016X14813914187138
IEEE Style
H. Geng, R. Cao, L. Cheng, and C. Liu "Overexpression of Hepatocyte Cell Adhesion Molecule (hepaCAM) Inhibits the Proliferation, Migration, and Invasion in Colorectal Cancer Cells," Oncol. Res., vol. 25, no. 7, pp. 1039-1046. 2017. https://doi.org/10.3727/096504016X14813914187138



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 47

    View

  • 23

    Download

  • 0

    Like

Share Link