Oncology Research Editorial Office

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.081284 - 23 March 2026

Abstract This article has no abstract. More >

Yiran Dong¹, Jingyue Wang¹, Jiayang Chen², Liang Mo², Yong You^1,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.075191 - 23 March 2026

Abstract Background: Lung adenocarcinoma (LUAD), the most prevalent histological subtype of lung cancer, remains a leading cause of cancer-related mortality due to late diagnosis, metastasis, and therapy resistance. The aim of the study is to investigate the role of Kinetochore Scaffold 1 (KNL1) in promoting LUAD progression and its underlying molecular regulatory mechanisms. Methods: KNL1 mRNA expression levels across 33 cancer types were analyzed using bioinformatics analysis based on the TCGA database. Immunohistochemistry (IHC) was used to assess KNL1 expression in LUAD and normal tissues. Stable KNL1-knockdown and KNL1-overexpressing LUAD cell lines were established using lentiviral… More >

Crystal J. Byrd¹, Monasia Evans¹, Woojung Kim², Quintera Knight³, Geou-Yarh Liou^1,2,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2025.073532 - 23 March 2026

Abstract Objective: The progression of prostate cancer cells to metastasis is supported by their tumor microenvironment. Within this microenvironment, infiltrating immune cells, such as B cells, can be either anti-tumorigenic or pro-tumorigenic. Our preliminary data showed that a higher density of the infiltrating B cells was found near prostate cancer cells in human cancer tissues, as compared to the benign prostate tissue regions, thus suggesting that infiltrating B cells would promote the progression of prostate cancer cells. In this study, we aim to investigate the role of infiltrating B cells in enhancing the migratory ability of… More >

So-Ye Jeon^1,#, Zeeshan Ahmad Bhutta^1,#, Hong Kyu Lee², Kyung-Chul Choi^1,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.071328 - 23 March 2026

Abstract Objectives: Progesterone (P4) is believed to inhibit breast cancer growth, but its role in counteracting estrogen (E2)-driven progression remains unclear. This study aimed to investigate the inhibitory effect of P4 on E2-induced cell proliferation, migration, and invasion in Estrogen receptor (ER)+/progesterone receptor (PR)+ breast cancer cells by examining its regulatory role in the epithelial-mesenchymal transition (EMT). Methods: ER and PR-positive MCF-7 clonal variant (MCF-7 CV) breast cancer cells were treated with E2 and co-treated with various concentrations of P4. The effects on cell proliferation, migration, and invasion were assessed. The expression of key EMT markers… More >

Jo-Yu Lin^1,#, Tien-Huang Lin^2,3,#, Ya-Jing Jiang⁴, Liang-Wei Lin⁴, Kuan-Ying Lai⁵, Yi-Chin Fong^6,7,8, Chih-Chuang Liaw^5,9,*, Chih-Hsin Tang^1,4,10,11,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.074202 - 24 February 2026

Abstract Background: Prostate cancer (PCa) is the most prevalent malignancy in men and often correlates with distant metastasis in its advanced stages. The study aimed to investigate the effects of Ugonin J, a natural compound isolated from Helminthostachys zeylanica, on PCa metastasis. Methods: The effects of Ugonin J on cell motility were assessed using migration and invasion assays. Reverse Transcription Quantitative PCR (RT-qPCR) and Western blotting were used to evaluate the impact of Ugonin J on mRNA and protein expression. RNA sequencing (RNA-seq) analysis was performed to investigate candidate mechanisms. Differential gene expression analysis in PCa patients… More >

Hang Zhang^1,#, Meng-Yuan Chu^1,#, Guohui Lv¹, You-Jie Li¹, Xuhang Liu², Fei Jiao^1,*, Yun-Fei Yan^1,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.068322 - 23 January 2026

Abstract Objectives: Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with limited understanding of lncRNA-driven mechanisms in tumor progression. This study aimed to identify differentially expressed lncRNAs in NSCLC tissues and elucidate the functional role of the significantly upregulated RP3-340N1.2 in promoting malignancy. Methods: RNA sequencing was used to screen dysregulated lncRNAs. RP3-340N1.2 was functionally characterized via gain/loss-of-function assays in NSCLC cells, assessing proliferation, migration, and macrophage polarization. Mechanisms of interleukin 6 (IL-6) regulation were explored using cytokine profiling, Actinomycin D assays, and RNA Immunoprecipitation (RIP) assays to study RP3-340N1.2 interactions with… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.077269 - 30 December 2025

Abstract This article has no abstract. More >

Quan Cheng, Yun Lin, Hui Yu^*

International Journal of Mental Health Promotion, Vol.27, No.12, pp. 1961-1988, 2025, DOI:10.32604/ijmhp.2025.072232 - 31 December 2025

Abstract Background: Against the backdrop of the complex interplay between global migration flows and the European Union’s governance system, immigrants’ subjective well-being (SWB) has become a crucial indicator for assessing both their social integration and the effectiveness of integration policies. However, few studies have systematically linked immigration law and policy to SWB through a structured framework of human needs. This study aims to assess how European Union (EU) immigration policies influence immigrants’ SWB by facilitating the fulfillment of hierarchical needs based on Maslow’s theory. Methods: Using data from the European Social Survey (ESS, 2010–2023), this study analyzed… More >

Oncology Research Editorial Offfce

Oncology Research, Vol.33, No.12, pp. 4155-4155, 2025, DOI:10.32604/or.2025.075990 - 27 November 2025

Abstract This article has no abstract. More >

Yingjie Wang^1,#, Wanlin Dong^1,#, Can Wang², Zirui Li¹, Yongqiang Wang¹, Qi Li¹, Cheng-Ya Dong^1,*

Oncology Research, Vol.33, No.12, pp. 4093-4111, 2025, DOI:10.32604/or.2025.068313 - 27 November 2025

Abstract Objectives: Glioblastoma is a prevalent malignant brain tumor, and the actions of the long non-coding RNA HOXA10-AS in its invasion and migration remain unclear. Here, the function of HOXA10-AS in glioblastoma cell invasion and migration and associated mechanisms were investigated. Methods: HOXA10-AS was knocked down in glioblastoma cells, and Transwell and wound healing assays were conducted to elucidate its impacts on cell invasion and migration. Western blotting and quantitative reverse transcription polymerase chain reaction (qRT-PCR) assessed HOXA10-AS’s impact on the epithelial-mesenchymal transition (EMT). Microarray analysis identified differentially expressed genes, complemented by bioinformatics approaches to explore… More >