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  • Open Access

    ARTICLE

    UCK2 promotes the proliferation, migration, and invasion of trophoblast cells in preeclampsia by activating the STAT3 pathway

    WEI XIA1, NING YANG2, XIAOYAN FENG3, TING XIN1, YONGLE JING1, YUMING LI4,*, CHENGZHI LU1,5,*

    BIOCELL, Vol.47, No.4, pp. 837-847, 2023, DOI:10.32604/biocell.2023.026161

    Abstract Background: Preeclampsia (PE), characterized by hypertension and proteinuria, leads to serious maternal and infant complications. Uridine-cytidine kinase 2 (UCK2) belongs to the UCK family, a class of enzymes that catalyzes the conversion of uridine and cytidine to monophosphate form. However, the role of UCK2 in PE has not been reported. Methods: The expression of UCK2 was detected in the placenta of PE patients and N(ω)-nitro-L-arginine methyl esterinduced PE mouse model. Through forced up-regulation or down-regulation of UCK2 in vitro, we examined the effects of UCK2 on the proliferation, apoptosis, migration, and invasion of trophoblast cells. Stattic, the inhibitor of STAT3… More >

  • Open Access

    REVIEW

    How is the AKT/mTOR pathway involved in cell migration and invasion?

    JINGYAO XU1,#, SHUANGLI HAO1,#, KAIYUE HAN1,#, WANXI YANG1,*, HONG DENG2,*

    BIOCELL, Vol.47, No.4, pp. 773-788, 2023, DOI:10.32604/biocell.2023.026618

    Abstract As a pathway that plays a role in nutrient absorption, anabolic response, cell growth and survival, the important role of AKT/mTOR in tumorigenesis has also come to light. For cancer patients, most deaths are caused by the growth of metastatic tumors outside the primary focus. Therefore, migration and invasion in the late stage of tumor progression are the main unresolved issues in the study of tumor pathogenesis, and AKT/mTOR has been found to participate in the migration and invasion of cancer cells, which means that the study of this pathway may contribute to a solution for the problem. Because of… More >

  • Open Access

    ARTICLE

    Semaphorin 7A promotes human vascular smooth muscle cell proliferation and migration through the β-catenin signaling pathway

    XIAOSU SONG, FEN GAO, HONG LI, WEIWEI QIN, CHANJUAN CHAI, GUOJUAN SHI, HUIYU YANG*

    BIOCELL, Vol.47, No.4, pp. 849-858, 2023, DOI:10.32604/biocell.2023.026545

    Abstract Background: Vascular smooth muscle cells (VSMCs) undergo a conversion from a contractile phenotype to a proliferative synthetic phenotype, contributing to the pathogenesis of cardiovascular diseases. Semaphorin 7A (SEMA7A) is a glycosylphosphatidylinositol-anchored membrane protein that plays an important role in vascular homeostasis by regulating endothelial cell behaviors. However, the expression and role of SEMA7A in VSMCs remain unclear.Methods: In this study, we screened for VSMC-regulating genes in publicly available datasets and analyzed the expression of SEMA7A in human coronary artery smooth muscle cells (hCASMCs) treated with platelet-derived growth factor-BB (PDGF-BB). The effects of SEMA7A overexpression and knockdown on hCASMC proliferation and… More >

  • Open Access

    ARTICLE

    Has_circ_0000069 expression in breast cancer and its influences on prognosis and cellular activities

    GANG WANG#, MINGPING QIAN#, WEI JIAN, JUHANG CHU, YIXIANG HUANG*

    Oncology Research, Vol.31, No.1, pp. 63-70, 2023, DOI:10.32604/or.2022.028168

    Abstract Circular RNA (circRNA), as a newly discovered non-coding RNA with important regulatory potential, is closely related to the occurrence and progression of various tumors. This study aimed to investigate has_circ_0000069 expression in breast cancer and its influence on cellular activities. Using real-time quantitative polymerase chain reaction, has_circ_0000069 levels were measured in 137 pairs of tissue specimens, as well as cancer cell lines. The cellular activities of cell lines were determined by cell counting kit-8 (CCK-8) and Transwell assays. The potential targeting miRNAs were predicted and verified using an online database and dual-luciferase reporter assay. Has_circ_0000069 was highly expressed in breast… More >

  • Open Access

    ARTICLE

    Evaluation of Water Transfer Capacity of Poplar with Pectinase Treated under the Solar Interface Evaporation

    Wei Xiong1,2, Dagang Li1,*, Peixing Wei2, Lin Wang2, Qian Feng1

    Journal of Renewable Materials, Vol.11, No.5, pp. 2265-2278, 2023, DOI:10.32604/jrm.2023.025483

    Abstract Poplar wood, which was used as the absorption material for the solar-driven interfacial evaporation, was treated for 3 days, 6 days and 9 days with the pectinase, and then was simulated for photothermal evaporation test at one standard solar radiation intensity (1 kW⋅m−2). The effects of pectinase treatment on cell passage and water migration capacity of poplars were analyzed by the mercury intrusion porosimetry, the scanning electron microscope and fractal theory. It was found that the pit membrane and the ray parenchyma cells of poplar wood were degraded and destroyed after pectinase treatment. Compared with the untreated poplar wood, the evaporation… More >

  • Open Access

    ARTICLE

    MiR-145-5p Suppresses Hepatocellular Carcinoma Progression by Targeting ABHD17C

    Linpei Wang1,#, Xiaoqiu Ma2,#, Youqi Chen1, Jiahui Zhang1, Jiawei Zhang1, Wei Wang1,*, Shaojian Chen3,*

    Oncologie, Vol.24, No.4, pp. 897-912, 2022, DOI:10.32604/oncologie.2022.025693

    Abstract Background: MicroRNA-145-5p (miR-145-5p) reportedly inhibits hepatocellular carcinoma (HCC) by targeting ARF6, SPATS2, CDCA3, KLF5, and NRAS, indicating that miR-145-5p plays an important role in the occurrence and development of HCC by regulating the expression of various genes. In this study, we aimed to explore novel downstream targets of miR-145-5p and elucidate the potential mechanism of miR-145-5p in HCC. Materials and Methods: A bioinformatics analysis was performed to determine the clinical significance of miR-145-5p and alpha/beta hydrolase domain-containing protein 17C (ABHD17C) in patients with HCC. The ability of Hep3B cells to proliferate, migrate, and invade was examined after overexpression of miR-145-5p… More >

  • Open Access

    ARTICLE

    Performance Framework for Virtual Machine Migration in Cloud Computing

    Tahir Alyas1, Taher M. Ghazal2,3, Badria Sulaiman Alfurhood4, Munir Ahmad5, Ossma Ali Thawabeh6, Khalid Alissa7, Qaiser Abbas8,*

    CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 6289-6305, 2023, DOI:10.32604/cmc.2023.035161

    Abstract In the cloud environment, the transfer of data from one cloud server to another cloud server is called migration. Data can be delivered in various ways, from one data centre to another. This research aims to increase the migration performance of the virtual machine (VM) in the cloud environment. VMs allow cloud customers to store essential data and resources. However, server usage has grown dramatically due to the virtualization of computer systems, resulting in higher data centre power consumption, storage needs, and operating expenses. Multiple VMs on one data centre manage share resources like central processing unit (CPU) cache, network… More >

  • Open Access

    REVIEW

    The role of YAP in the control of the metastatic potential of oral cancer

    USAMA SHARIF AHMAD, KARTHIK SARAVANAN, HONG WAN*

    Oncology Research, Vol.29, No.6, pp. 377-391, 2021, DOI:10.32604/or.2022.026085

    Abstract The Yes-associated protein (YAP) is a downstream effector of the Hippo pathway and acts as a key transcription co-factor to regulate cell migration, proliferation, and survival. The Hippo pathway is evolutionarily conserved and controls tissue growth and organ size. Dysregulation and heterogeneity of this pathway are found in cancers, including oral squamous cell carcinoma (OSCC), leading to overexpression of YAP and its regulated proliferation machinery. The activity of YAP is associated with its nuclear expression and is negatively regulated by the Hippo kinase-mediated phosphorylation resulting in an induction of its cytoplasmic translocation. This review focuses on the role of YAP… More >

  • Open Access

    ARTICLE

    Edge Computing Platform with Efficient Migration Scheme for 5G/6G Networks

    Abdelhamied A. Ateya1, Amel Ali Alhussan2,*, Hanaa A. Abdallah3, Mona A. Al duailij2, Abdukodir Khakimov4, Ammar Muthanna5

    Computer Systems Science and Engineering, Vol.45, No.2, pp. 1775-1787, 2023, DOI:10.32604/csse.2023.031841

    Abstract Next-generation cellular networks are expected to provide users with innovative gigabits and terabits per second speeds and achieve ultra-high reliability, availability, and ultra-low latency. The requirements of such networks are the main challenges that can be handled using a range of recent technologies, including multi-access edge computing (MEC), artificial intelligence (AI), millimeter-wave communications (mmWave), and software-defined networking. Many aspects and design challenges associated with the MEC-based 5G/6G networks should be solved to ensure the required quality of service (QoS). This article considers developing a complex MEC structure for fifth and sixth-generation (5G/6G) cellular networks. Furthermore, we propose a seamless migration… More >

  • Open Access

    ARTICLE

    Improved Metaheuristic Based Failure Prediction with Migration Optimization in Cloud Environment

    K. Karthikeyan1,*, Liyakathunisa2, Eman Aljohani2, Thavavel Vaiyapuri3

    Computer Systems Science and Engineering, Vol.45, No.2, pp. 1641-1654, 2023, DOI:10.32604/csse.2023.031582

    Abstract Cloud data centers consume high volume of energy for processing and switching the servers among different modes. Virtual Machine (VM) migration enhances the performance of cloud servers in terms of energy efficiency, internal failures and availability. On the other end, energy utilization can be minimized by decreasing the number of active, underutilized sources which conversely reduces the dependability of the system. In VM migration process, the VMs are migrated from underutilized physical resources to other resources to minimize energy utilization and optimize the operations. In this view, the current study develops an Improved Metaheuristic Based Failure Prediction with Virtual Machine… More >

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