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  • Open Access

    ARTICLE

    A Novel Attack on Complex APUFs Using the Evolutionary Deep Convolutional Neural Network

    Ali Ahmadi Shahrakht1, Parisa Hajirahimi2, Omid Rostami3, Diego Martín4,*

    Intelligent Automation & Soft Computing, Vol.37, No.3, pp. 3059-3081, 2023, DOI:10.32604/iasc.2023.040502

    Abstract As the internet of things (IoT) continues to expand rapidly, the significance of its security concerns has grown in recent years. To address these concerns, physical unclonable functions (PUFs) have emerged as valuable tools for enhancing IoT security. PUFs leverage the inherent randomness found in the embedded hardware of IoT devices. However, it has been shown that some PUFs can be modeled by attackers using machine-learning-based approaches. In this paper, a new deep learning (DL)-based modeling attack is introduced to break the resistance of complex XAPUFs. Because training DL models is a problem that falls under the category of NP-hard… More >

  • Open Access

    PROCEEDINGS

    Atomistic Simulations on the Shock Response of Nanoscale He Bubble in Metal

    Jianli Shao1,2,*, Weidong Wei1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2023.09101

    Abstract This report mainly introduces our recent research on the shock-induced collapse, migration and coalescence of He bubbles in metal based on atomistic simulations. The He bubble will be compressed to permanent deformation with the finite plastic collapse of metal. Under strong shock, the He bubble can be breakdown by the nano-jet of the metal, but it returns to a reduced sphere in the molten metal after long-time evolution, driven by the He-Al interface energy. Besides, the shock-induced migration of He bubble is revealed, which can be divided into shock acceleration and the following inertial motion. Moreover, two coalescence modes caused… More >

  • Open Access

    PROCEEDINGS

    Atomistic Migration Mechanisms of [1210] Symmetric Tilt Grain Boundaries in Magnesium

    Chuanlong Xu1, Haidong Fan1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.010110

    Abstract Grain boundary (GB) is an important microstructure and plays a vital role in the mechanical properties of polycrystalline materials by GB migration and sliding. In this work, molecular dynamic (MD) simulations were performed to investigate the migration mechanisms of symmetric tilt grain boundaries (STGBs) in magnesium. A total of 15 STGBs with the rotation angle θ from 0° to 90° were studied under a pure shear loading. The results show that the GB migration mechanisms are significantly influenced by the GB structure. For small angle STGBs (θ<28°), the GB migration is mediated by twin nucleation from GB… More >

  • Open Access

    ARTICLE

    Biochanin A, as the Lrg1/TGF-β/Smad2 pathway blockade, attenuates blood-brain barrier damage after cerebral ischemia-reperfusion by modulating leukocyte migration patterns

    LONGSHENG FU1, JINFANG HU1, FENG SHAO2, YAOQI WU1, WEI BAI3, MINGJIN JIANG3, HAO CHEN4, LIHUA CHEN2, YANNI LV1,*

    BIOCELL, Vol.47, No.8, pp. 1869-1883, 2023, DOI:10.32604/biocell.2023.028602

    Abstract Background: Biochanin A is an excellent dietary isoflavone that has the concomitant function of both medicine and foodstuff. The attenuation function of biochanin A on blood-brain barrier (BBB) damage induced by cerebral ischemia-reperfusion remains unclear. Methods: C57BL/6 mice were subjected to 1 h middle cerebral artery occlusion (MCAO) followed by 24 h reperfusion. The infarct volume of the brain was stained by TTC, while leakage of the brain was quantitatively stained by Evans blue, and the neurologic deficit score was measured. Microglial-induced morphologic changes were observed via immunofluorescence staining, and rolling and adhering leukocytes in venules were observed via two-photon… More >

  • Open Access

    ARTICLE

    Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway

    TIANYING CAI1,2, JUNJIE BAI1, PENG TAN3, ZHIWEI HUANG1, CHEN LIU1, ZIMING WU1, YONGLANG CHENG1, TONGXI LI1, YIFAN CHEN1, JIAN RUAN4, LIN GAO5, YICHAO DU3,*, WENGUANG FU1,3,*

    Oncology Research, Vol.31, No.5, pp. 805-817, 2023, DOI:10.32604/or.2023.029549

    Abstract Hepatocellular carcinoma (HCC) is a common malignancy that is driven by multiple genes and pathways. The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin (ZYX) in HCC. We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues. In addition, overexpression of ZYX in hepatoma cell lines (PLC/PRF/5, HCCLM3) enhanced their proliferation, migration and invasion, whereas ZYX knockdown had the opposite effects (SK HEP-1, Huh-7). Furthermore, the change in the expression levels of ZYX also altered that of proteins related to cell… More >

  • Open Access

    ARTICLE

    Migration Algorithm: A New Human-Based Metaheuristic Approach for Solving Optimization Problems

    Pavel Trojovský*, Mohammad Dehghani

    CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.2, pp. 1695-1730, 2023, DOI:10.32604/cmes.2023.028314

    Abstract This paper introduces a new metaheuristic algorithm called Migration Algorithm (MA), which is helpful in solving optimization problems. The fundamental inspiration of MA is the process of human migration, which aims to improve job, educational, economic, and living conditions, and so on. The mathematical modeling of the proposed MA is presented in two phases to empower the proposed approach in exploration and exploitation during the search process. In the exploration phase, the algorithm population is updated based on the simulation of choosing the migration destination among the available options. In the exploitation phase, the algorithm population is updated based on… More >

  • Open Access

    ARTICLE

    LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral squamous carcinoma

    FAYU SHAN1, LANLAN LIANG1, CHONG FENG1, HONGBAO XU1, ZIROU WANG1, WEILI LIU1, LINGLING PU1, ZHAOLI CHEN1, GANG CHEN2,*, XINXING WANG1,*

    Oncology Research, Vol.31, No.4, pp. 481-493, 2023, DOI:10.32604/or.2023.029064

    Abstract Background: Oral squamous cell carcinoma (OSCC) is a common malignant tumor. Recently, Laminin Gamma 2 (LAMC2) has been shown to be abnormally expressed in OSCC; however, how LAMC2 signaling contributes to the occurrence and development of OSCC and the role of autophagy in OSCC has not been fully explored. This study aimed to analyze the role and mechanism of LAMC2 signaling in OSCC and the involvement of autophagy in OSCC. Methods: To explore the mechanism by which LAMC2 is highly expressed in OSCC, we used small interfering RNA (siRNA) to knock down LAMC2 to further observe the changes in the… More >

  • Open Access

    ARTICLE

    PPARα activator irbesartan suppresses the proliferation of endometrial carcinoma cells via SREBP1 and ARID1A

    YU LU1, TSUTOMU MIYAMOTO1,*, HODAKA TAKEUCHI1, FUMI TSUNODA1, NAOKI TANAKA2,3,4, TANRI SHIOZAWA1

    Oncology Research, Vol.31, No.3, pp. 239-253, 2023, DOI:10.32604/or.2023.026067

    Abstract Endometrial carcinoma (EMC) is associated with obesity; however, the underlying mechanisms have not yet been elucidated. Peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear receptor that is involved in lipid, glucose, and energy metabolism. PPARα reportedly functions as a tumor suppressor through its effects on lipid metabolism; however, the involvement of PPARα in the development of EMC remains unclear. The present study demonstrated that the immunohistochemical expression of nuclear PPARα was lower in EMC than in normal endometrial tissues, suggesting the tumor suppressive nature of PPARα. A treatment with the PPARα activator, irbesartan, inhibited the EMC cell lines, Ishikawa and… More >

  • Open Access

    ARTICLE

    Vitamin D attenuates TGF-β1-induced lung fibroblast proliferation and migration through repression of RasGRP3

    GUANQIONG HU1, RISHENG HUANG2, LUELUE LU1, QINSHI PAN3, XIAOXIN CHEN1,*

    BIOCELL, Vol.47, No.6, pp. 1243-1251, 2023, DOI:10.32604/biocell.2023.027763

    Abstract Background: Transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine that plays a central role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). While previous studies have revealed a cross-talk between vitamin D and TGF-β1 signaling, it is still unclear how they interact with each other to regulate the progression of IPF. Methods: In this work, we searched for a novel mediator of TGF-β1 activity in lung fibroblasts and examined its regulation by vitamin D. In addition, we investigated the mechanism underlying the interaction between vitamin D and TGF-β1 signaling in lung fibroblast activation. Bioinformatic analysis was performed to identify TGF-β1… More >

  • Open Access

    ARTICLE

    Container-Based Internet of Vehicles Edge Application Migration Mechanism

    Sujie Shao, Shihan Tian*, Shaoyong Guo, Xuesong Qiu

    CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 4867-4891, 2023, DOI:10.32604/cmc.2023.038280

    Abstract Internet of Vehicles (IoV) applications integrating with edge computing will significantly drive the growth of IoV. However, the contradiction between the high-speed mobility of vehicles, the delay sensitivity of corresponding IoV applications and the limited coverage and resource capacity of distributed edge servers will pose challenges to the service continuity and stability of IoV applications. IoV application migration is a promising solution that can be supported by application containerization, a technology forseamless cross-edge-server application migration without user perception. Therefore, this paper proposes the container-based IoV edge application migration mechanism, consisting of three parts. The first is the migration trigger determination… More >

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