Table of Content

Open Access iconOpen Access

ARTICLE

MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2

Geqiong Xiao*, Qiong Wang*, Bo Li, Xiaohui Wu, Hui Liao*, Yili Ren*, Ning Ai†*

* Department of Oncology, ShaoXing Municipal Hospital, Shaoxing, Zhejiang, P.R. China
† Department of Interventional Radiology, The 4th Hospital of Hebei Medical University, Shi Jiazhuang, Hebei, P.R. China
‡ Department of Hepatobiliary Surgery, The 4th Hospital of Hebei Medical University, Shi Jiazhuang, Hebei, P.R. China

Oncology Research 2018, 26(8), 1183-1189. https://doi.org/10.3727/096504018X15151495109394

Abstract

Recent studies have revealed abnormal expression of miRNAs in various tumors. Although microRNA-338-3p (miR-338-3p) plays an important role in many types of tumors, its influence on liver cancer (LC) is unknown. In this study, we found that expression of miR-338-3p was decreased in LC cells and tissues. Colony formation and cell proliferation were suppressed by enhanced expression of miR-338-3p in LC cells. Moreover, miR-338-3p targeted sphingosine kinase 2 (SphK2). Silencing of SphK2 had an identical influence as overexpression of miR-338-3p in LC cells. Overexpression of SphK2 without the 3'-untranslated region remarkably enhanced the growth suppression triggered by miR-338-3p in LC cells. These findings indicate that miR- 338-3p influences the development of LC by targeting SphK2, suggesting that miR-338-3p can be targeted as an innovative therapeutic strategy for LC.

Keywords


Cite This Article

APA Style
Xiao, G., Wang, Q., Li, B., Wu, X., Liao, H. et al. (2018). Microrna-338-3p suppresses proliferation of human liver cancer cells by targeting sphk2. Oncology Research, 26(8), 1183-1189. https://doi.org/10.3727/096504018X15151495109394
Vancouver Style
Xiao G, Wang Q, Li B, Wu X, Liao H, Ren Y, et al. Microrna-338-3p suppresses proliferation of human liver cancer cells by targeting sphk2. Oncol Res. 2018;26(8):1183-1189 https://doi.org/10.3727/096504018X15151495109394
IEEE Style
G. Xiao et al., "MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2," Oncol. Res., vol. 26, no. 8, pp. 1183-1189. 2018. https://doi.org/10.3727/096504018X15151495109394



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 55

    View

  • 54

    Download

  • 0

    Like

Share Link