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MicroRNA-139-5p Inhibits Cell Proliferation and Invasion by Targeting RHO-Associated Coiled-Coil-Containing Protein Kinase 2 in Ovarian Cancer

Yanli Wang*, Jia Li, Chunling Xu, Xiaomeng Zhang

* Department of Gynecology, The First Hospital of Jilin University, Changchun, P.R. China
† Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, P.R. China

Oncology Research 2020, 28(7-8), 823-825. https://doi.org/10.3727/096504021X16240202940021

Abstract

Increasing evidence indicates that the dysregulation of microRNAs is associated with the development and progression of various cancers. MicroRNA-139-5p (miR-139-5p) has been reported to have a tumor suppressive role in many types of cancers. The role of miR-139-5p in ovarian cancer (OC) is poorly understood. The purpose of the present study was to explore the expression of miR-139-5p and its function in OC. The results showed that miR-139-5p expression was markedly downregulated in OC tissues and cell lines. In addition, underexpression of miR-139-5p was significantly associated with FIGO stage, lymph mode metastasis, and poor overall survival of OC patients. Functional analyses indicated that overexpression of miR-139-5p significantly inhibited proliferation, colony formation, migration, and invasion of OC cells. Rho-associated coiledcoil-containing protein kinase 2 (ROCK2) was identified as a direct target of miR-139-5p using luciferase reporter assays, qualitative real-time reverse transcriptase PCR (qRT-PCR), and Western blot. In addition, ROCK2 expression was upregulated and was inversely correlated with miR-139-5p levels in OC tissues. Rescue experiments showed that overexpression of ROCK2 effectively reversed the inhibitory effect of OC cells induced by miR-139-5p. Most interestingly, in vivo studies indicated that miR-139-5p markedly suppressed the growth of tumors by repressing ROCK2 expression in nude mice. Taken together, these findings demonstrated that miR-139-5p plays an important tumor suppressor role in OC by directly binding to ROCK2, providing a novel target for the molecular treatment of OC.

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APA Style
Wang, Y., Li, J., Xu, C., Zhang, X. (2020). Microrna-139-5p inhibits cell proliferation and invasion by targeting rho-associated coiled-coil-containing protein kinase 2 in ovarian cancer. Oncology Research, 28(7-8), 823-825. https://doi.org/10.3727/096504021X16240202940021
Vancouver Style
Wang Y, Li J, Xu C, Zhang X. Microrna-139-5p inhibits cell proliferation and invasion by targeting rho-associated coiled-coil-containing protein kinase 2 in ovarian cancer. Oncol Res. 2020;28(7-8):823-825 https://doi.org/10.3727/096504021X16240202940021
IEEE Style
Y. Wang, J. Li, C. Xu, and X. Zhang "MicroRNA-139-5p Inhibits Cell Proliferation and Invasion by Targeting RHO-Associated Coiled-Coil-Containing Protein Kinase 2 in Ovarian Cancer," Oncol. Res., vol. 28, no. 7-8, pp. 823-825. 2020. https://doi.org/10.3727/096504021X16240202940021



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