Open Access

COMMENTARY

Game-changing insights on vertebral skeletal stem cells in bone metastasis and therapeutic horizons

QIUQIANG CHEN^1,*, XIAOLEI ZHAO², WENXUE MA^3,*

1 Key Laboratory for Translational Medicine, The First Affiliated Hospital, Huzhou University School of Medicine, Huzhou, 313000, China
2 Department of Urology, Huaihe Hospital of Henan University, Kaifeng, 475004, China
3 Department of Medicine, Moores Cancer Center, Sanford Stem Cell Institute, University of California San Diego, La Jolla, 92093, USA

* Corresponding Authors: Qiuqiang Chen, ; Wenxue Ma,

Oncology Research 2024, 32(1), 95-98. https://doi.org/10.32604/or.2023.046174

Received 14 September 2023; Accepted 20 September 2023; Issue published 15 November 2023

Abstract

Greenblatt and his team have unveiled vertebral skeletal stem cells (vSSCs) as a critical player in the landscape of bone metastasis. This commentary delves into the transformative discoveries surrounding vSSCs, emphasizing their distinct role in bone metastasis compared to other stem cell lineages. We illuminate the unique properties and functions of vSSCs, which may account for the elevated susceptibility of vertebral bones to metastatic invasion. Furthermore, we explore the exciting therapeutic horizons opened by this newfound understanding. These include potential interventions targeting vSSCs, modulation of associated signaling pathways, and broader implications for the treatment and management of bone metastasis. By shedding light on these game-changing insights, we hope to pave the way for novel strategies that could revolutionize the prognosis and treatment landscape for cancer patients with metastatic bone disease.

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