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Glutamine transporters as effective targets in digestive system malignant tumor treatment

FEI CHU1, KAI TONG1, XIANG GU1, MEI BAO1, YANFEN CHEN1, BIN WANG2, YANHUA SHAO1, LING WEI1,*

1 School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, 510006, China
2 Department of Pharmacy, Tianjin Medical University General Hospital, Tianjin, 300070, China

* Corresponding Author: LING WEI. Email: email

Oncology Research 2024, 32(10), 1661-1671. https://doi.org/10.32604/or.2024.048287

Abstract

Glutamine is one of the most abundant non-essential amino acids in human plasma and plays a crucial role in many biological processes of the human body. Tumor cells take up a large amount of glutamine to meet their rapid proliferation requirements, which is supported by the upregulation of glutamine transporters. Targeted inhibition of glutamine transporters effectively inhibits cell growth and proliferation in tumors. Among all cancers, digestive system malignant tumors (DSMTs) have the highest incidence and mortality rates, and the current therapeutic strategies for DSMTs are mainly surgical resection and chemotherapy. Due to the relatively low survival rate and severe side effects associated with DSMTs treatment, new treatment strategies are urgently required. This article summarizes the glutamine transporters involved in DSMTs and describes their role in DSMTs. Additionally, glutamine transporter-target drugs are discussed, providing theoretical guidance for the further development of drugs DSMTs treatment.

Graphic Abstract

Glutamine transporters as effective targets in digestive system malignant tumor treatment

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APA Style
CHU, F., TONG, K., GU, X., BAO, M., CHEN, Y. et al. (2024). Glutamine transporters as effective targets in digestive system malignant tumor treatment. Oncology Research, 32(10), 1661-1671. https://doi.org/10.32604/or.2024.048287
Vancouver Style
CHU F, TONG K, GU X, BAO M, CHEN Y, WANG B, et al. Glutamine transporters as effective targets in digestive system malignant tumor treatment. Oncol Res. 2024;32(10):1661-1671 https://doi.org/10.32604/or.2024.048287
IEEE Style
F. CHU et al., "Glutamine transporters as effective targets in digestive system malignant tumor treatment," Oncol. Res., vol. 32, no. 10, pp. 1661-1671. 2024. https://doi.org/10.32604/or.2024.048287



cc Copyright © 2024 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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