KAIWEN TIAN^#, HANZHONG CHEN^#, QIANQIAN WANG, FENGLIAN JIANG, CHUNXIANG FENG, TENG LI, XIAOYONG PU, YANLIN TANG^*, JIUMIN LIU^*

BIOCELL, Vol.48, No.5, pp. 817-834, 2024, DOI:10.32604/biocell.2024.048737

Abstract Background: The incidence of clear cell renal cell carcinoma (ccRCC) is globally high; however, despite the introduction of innovative drug therapies, there remains a lack of effective biomarkers for evaluating treatment response. Recently, Caspase recruiting domain-containing protein 11 (CARD11) has garnered attention due to its significant association with tumor development and the immune system. Methods: The expression of CARD11 mRNA and protein in ccRCC were analyzed by public database and immunohistochemistry. The focus of this study is on the epigenomic modifications of CARD11, its expression of ccRCC immunophenotype, and its correlation with response to immunotherapy and targeted therapy. Furthermore, to… More > Graphic Abstract

QIN LIU^1,#, CHUNYAN NIU^2,#,*, QIANG ZHANG³, SHIQIN SUN⁴, YUE CHEN², YONGQIANG SHI²

BIOCELL, Vol.48, No.5, pp. 759-769, 2024, DOI:10.32604/biocell.2024.048551

Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is a global health concern with the acid sphingomyelinase (ASM)/ceramide (CE) pathway and the NOD-like receptor family, pyrin domain-containing protein 3 (NLRP3) inflammasome identified as pivotal players in lipid disorders and inflammation. This study explores the interaction mechanism between the ASM/CE pathway and NLRP3 in NAFLD cell models, aiming to understand the impact of amitriptyline (Ami), an ASM inhibitor, on lipid deposition and hepatocyte injury by regulating the ASM/CE-NLRP3 pathway. Methods: HepG2 and HL-7702 cells were exposed to free fatty acids (FFAs) to establish the NAFLD model. The cells were divided into 5 groups:… More >

XINRU FENG¹, LI XIAO^2,*

BIOCELL, Vol.48, No.5, pp. 793-801, 2024, DOI:10.32604/biocell.2024.048395

Abstract Background: Galectin 2 (LGALS2) is a protein previously reported to serve as a mediator of disease progression in a range of cancers. The function of LGALS2 in oral squamous cell carcinoma (OSCC), however, has yet to be explored, prompting the present study to address this literature gap. Methods: Overall, 144 paired malignant tumor tissues and paracancerous OSCC patient samples were harvested and the LGALS2 expression levels were examined through qPCR and western immunoblotting. The LGALS2 coding sequence was introduced into the pcDNA3.0 vector, to enable the overexpression of this gene, while an LGALS2-specific shRNA and corresponding controls were also obtained.… More >

XUAN SHI^1,2, YUFEN WANG¹, CHENYU LI¹, WANGSHU FU³, XINYUE ZHANG³, AIXIA GONG^1,*

BIOCELL, Vol.48, No.5, pp. 835-845, 2024, DOI:10.32604/biocell.2024.048076

Abstract Background: The incidence of colorectal cancer (CRC) has been increasing in recent years. Thus, the discovery of factors that can assist in alleviating CRC is urgently warranted. Methods: To identify a potential factor involved in the development of CRC, we screened the upregulated genes in tumor tissues through four datasets from an online database. The expression of reticulocalbin 1 (RCN1), a Ca-binding protein, was upregulated in the four datasets. Based on loss-of-function experiments, the effect of RCN1 on cell viability was assessed by Cell Counting Kit-8 (CCK-8) assay. The regulatory effect of RCN1 on apoptosis was evaluated through Annexin V-fluorescein… More > Graphic Abstract

JING HUI^1,2, NANA SUN³, YONG LIU⁴, CHUNBO YU^1,2, YONG KE⁴, YONG CAO⁴, ANXIAO YU⁴, QINGHONG KONG^1,2,*, YUN LIU^1,2,4,*

BIOCELL, Vol.48, No.5, pp. 803-815, 2024, DOI:10.32604/biocell.2024.047122

Abstract Background: Although it has been established that the human Solute Carrier Family 22 (SLC22) functions as a cationic transporter, influencing cellular biological metabolism by modulating the uptake of various cations, its impact on cancer prognosis remains unclear. Methods: We conducted a comprehensive analysis utilizing data from The Cancer Genome Atlas (TCGA) and other databases to assess the prognostic value and functional implications across various tumors. Silence of SLC22A1 RNA in glioma U251 cells was performed to access the impact of SLC22A1 on lower-grade glioma (LGG) progression. Results: Our findings demonstrated a significant correlation between SLC22A1 expression and the survival time… More >

Sowon Lee¹, Boyoung Kim^1,*, Chung Kil Park^2,*

International Journal of Mental Health Promotion, Vol.26, No.4, pp. 251-260, 2024, DOI:10.32604/ijmhp.2024.048803

Abstract This study explored how mental health professionals collaborate with peer supporters with mental disabilities in a community mental health institution. From January 19 to February 23, 2021, three 60 min interviews were conducted with six mental health professionals working at a Korean community center. The results were qualitatively analyzed and divided into four themes and eight categories. The four themes were the perceptions of and challenges in working with peer supporters with mental disabilities, conflict and confusion about working with peer supporters, forming partnerships with peer supporters, and policy support for peer supporters’ job security. Participants reported vague anxiety about… More >

Zhe Yu^1,2, Shuping Yang^1,*

International Journal of Mental Health Promotion, Vol.26, No.4, pp. 271-278, 2024, DOI:10.32604/ijmhp.2024.048342

Abstract This study aims to revise the Belief in a Just World Scale (BJWS) for Chinese college students and test its reliability and validity (construct validity, convergent and divergent validity). Two samples of 546 and 595 college students were selected, respectively, using stratified cluster random sampling. Item analysis, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), reliability analysis and convergent and divergent validity tests were carried out. The results showed that the 13 items of the BJWS have good item discrimination. The corrected item–total correlation in the general belief in a just world subscale was found to range from 0.464 to… More >

Brianna Cerrito^1,*, Jamie Xiao¹, Amie DiTomasso¹, Amanda Fialk¹, Jocelyn Bolin²

International Journal of Mental Health Promotion, Vol.26, No.4, pp. 317-323, 2024, DOI:10.32604/ijmhp.2024.047876

Abstract The purpose of the present study is to evaluate the internal consistency and construct validity of a self-report checklist measuring clinical mental health recovery across six key domains: family and relationships, occupation and school, physical health, mental health, spirituality, and social support systems. The Mental Health Recovery Checklist (MHRC) was developed at The Dorm, an intensive outpatient mental health treatment program for young adults in New York, NY, and Washington DC that services individuals between the ages of 18 and 35 years old. The present study is cross-sectional, as data were pulled from clients’ records who were discharged between January… More >

Kamolthip Ruckwongpatr^1,#, Chirawat Paratthakonkun^2,#, Usanut Sangtongdee^3,4,*, Iqbal Pramukti⁵, Ira Nurmala⁶, Kanokwan Angkasith⁷, Weena Thanachaisakul⁷, Jatuphum Ketchatturat⁸, Mark D. Griffiths⁹, Yi-Kai Kao^10,*, Chung-Ying Lin^1,5,11,12

International Journal of Mental Health Promotion, Vol.26, No.4, pp. 293-302, 2024, DOI:10.32604/ijmhp.2024.047023

Abstract Background: In recent years, there has been increased research interest in both smartphone addiction and social media addiction as well as the development of psychometric instruments to assess these constructs. However, there is a lack of psychometric evaluation for instruments assessing smartphone addiction and social media addiction in Thailand. The present study evaluated the psychometric properties and gender measurement invariance of the Thai version of the Smartphone Application-Based Addiction Scale (SABAS) and Bergen Social Media Addiction Scale (BSMAS). Method: A total of 801 Thai university students participated in an online survey from January 2022 to July 2022 which included demographic… More >

Yulei Chen¹, Zhaojun Chen^1,2, Shichao Wang¹, Yang Hang¹, Jianpeng Guo^1,*

International Journal of Mental Health Promotion, Vol.26, No.4, pp. 303-315, 2024, DOI:10.32604/ijmhp.2024.046863

Abstract Social-Emotional Competency (SEC), regarded as a critical psychological resource for individuals to adapt to social environments, is an effective protective factor for students’ mental health, impacting their future success and well-being. Analyzing the impact of SEC on university students’ mental health can offer valuable insights for nurturing talents with healthy psychological and physical development. Based on data from two large-scale surveys of Chinese university students, this study designed two comprehensive Multiple Mediation Models involving SEC, stress, coping strategies, and stress reaction to explore the pathway of emotion nurturing mentality. Study 1 utilized a parallel mediation model to examine the relationships… More >