Mohammadreza Nehzati^*

Journal on Artificial Intelligence, Vol.8, pp. 299-322, 2026, DOI:10.32604/jai.2026.082982 - 16 June 2026

Abstract Pedestrian detection in surveillance environments remains fundamentally challenging due to three coupled phenomena: severe occlusion, extreme scale variation, and low-resolution imagery. While contemporary detectors achieve high frame rates on standard benchmarks, they exhibit systematic failures under partial visibility where geometric consistency becomes the primary discriminative signal. This paper introduces a hybrid probabilistic framework that integrates Conditional Random Fields (CRF) with fractal geometry regularization to enforce scale invariant shape priors in deep pedestrian detectors. The core mathematical insight is that human silhouettes exhibit self-similarity across scales—a property precisely characterized by fractal dimension, self-similarity coefficients, and non-dimensionality… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.086727 - 16 June 2026

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.086722 - 16 June 2026

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.086719 - 16 June 2026

Abstract This article has no abstract. More >

Liang Li^1,#, Huijuan Liu^1,#, Lianjiang Du², Pan Xi¹, Qian Wang¹, Yanqin Li³, Di Liu^4,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.086717 - 16 June 2026

Abstract This article has no abstract. More >

Raquel Sanchez-Baltasar¹, Nerea Castañeda-Fernández¹, Jorge Olivares-Arancibia², Carlos Torres-Villar^3,4, Julio Plaza-Diaz^5,6,7,8,*, Lourdes Herrera-Quintana^1,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.081924 - 16 June 2026

Abstract Breast cancer (BC) is the most frequently diagnosed malignancy in women worldwide and remains one of the leading causes of cancer-related mortality, with substantial international disparities in incidence, stage at diagnosis, access to treatment, and survival. In recent years, BC management has evolved rapidly through advances in molecular characterization, imaging, pathology, targeted therapies, immunotherapy, and survivorship care. Nevertheless, important gaps persist in early and accurate detection, biomarker standardization, equitable access to care, and patient-specific treatment selection. These advances require timely, evidence-based, and context-specific clinical frameworks to support appropriate implementation, and to avoid the use of… More >

Zhengzheng Li^1,2,#, Haitong Xie^1,2,#, Yujuan Chen^1,2, Qiuyan Li³, Xing Yuan⁴, Xinyue Dai³, Jie Chen^1,2,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.081209 - 16 June 2026

Abstract Objectives: Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies. Phosphoglycerate kinase 1 (PGK1) drives TNBC progression, but mechanisms governing its protein stability remain unclear. This study aims to identify the E3 ubiquitin ligase responsible for PGK1 degradation and evaluate its therapeutic potential against metastasis. Methods: Clinical datasets and 50 human TNBC tissues were analyzed via multiplex immunohistochemistry. Co-immunoprecipitation, ubiquitination linkage assays, and structural modeling were utilized for in vitro mechanistic studies in TNBC cells. Additionally, functional impacts on epithelial-mesenchymal transition (EMT) and metastasis were evaluated using transwell assays and an in vivo mouse lung metastasis… More >

Yu-Hao Huang^1,#, Hao-Yeh Chen^2,#, Peng-Ju Chien¹, Chun-Yu Chen^2,3, Shao-Ti Li⁴, Hsueh-Te Lee⁵, Yueh-Chun Lee^4,6,*, Wen-Wei Chang^1,7,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.080978 - 16 June 2026

Abstract Backgrounds: Triple-negative breast cancer (TNBC) is highly aggressive, insensitive to radiotherapy, and exhibits increased cancer stem cell (CSC) properties, contributing to poor patient outcomes. B-cell lymphoma 2 (BCL2) associated transcription factor 1 (BCLAF1) is an oncogene in certain cancers, but its role in TNBC is unclear. This study investigated BCLAF1’s involvement in radioresistance and CSC activity in TNBC. Methods: BCLAF1 expression and clinical significance were analyzed using The Cancer Genome Atlas (TCGA) breast cancer dataset. Radioresistant MDA-MB-231 cells were used to examine BCLAF1’s function. Proto-oncogene SRC (SRC) overexpression, BCLAF1 knockdown, dasatinib treatment, and hypoxia inducible factor 1 subunit… More >

Guodong Yu^1,#, Weiying Ge^2,#, Hongliang Yao³, Xuefeng Bai¹, Jianfei Wu¹, Yuan Wang¹, Jiangtao Bai⁴, Yong Cui^1,*, Jijing Han^5,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.080746 - 16 June 2026

Abstract Hepatocellular carcinoma (HCC) develops in a chronically inflamed and dysregulated liver metabolism, in which tumor progression and resistance to treatment are orchestrated by the changes in cellular metabolism and immune control. Growing evidence recognizes immunometabolic reprogramming as the two-way interaction of metabolic processes and immune cell capabilities as one of the major determinants of immune evasion and heterogeneity of treatment response in HCC. The review aims to comprehensively evaluate immunometabolic reprogramming in hepatocellular carcinoma, with a focus on its role in tumor progression, immune regulation, and its potential for biomarker identification and therapeutic targeting. Dysregulated More >

Lei Luo¹, Fengju Guan¹, Zhankun Wang², Bin Li¹, Xuemei Ding¹, Leilei Song¹, Lijiang Sun^1,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.080621 - 16 June 2026

Abstract Background: Resistance to sunitinib represents a major clinical obstacle in the management of clear cell renal cell carcinoma (ccRCC). This investigation aims to identify genes associated with sunitinib resistance and elucidate potential molecular pathways in ccRCC. Methods: To identify differentially expressed genes (DEGs) in sunitinib-resistant ccRCC cells and their parental cells, bioinformatic analysis was performed on the GSE216494 dataset. Protein-protein interaction (PPI) network and topological analyses pinpointed a hub gene. Sunitinib-resistant A498 and 786-O cell lines were employed for in vitro validation. Sunitinib sensitivity and cell proliferation were evaluated using functional assays, such as colony formation and… More >