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    Evaluation of cytotoxic potential of latex of Calotropis procera and Podophyllotoxin in Allum cepa root model


    BIOCELL, Vol.30, No.1, pp. 9-13, 2006, DOI:10.32604/biocell.2006.30.009

    Abstract In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cytotoxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations. More >

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