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Evaluation of cytotoxic potential of latex of Calotropis procera and Podophyllotoxin in Allum cepa root model

R. SEHGAL, S. ROY, V.L. KUMAR*
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110 029, INDIA.
Address correspondence to: Dr. Vijay L. Kumar. Department of Pharmacology. All India Institute of Medical Sciences. Ansari Nagar, New Delhi-110 029, INDIA. Fax: (+91-11) 26588663. E-mail: kumarv198@hotmail.com

BIOCELL 2006, 30(1), 9-13. https://doi.org/10.32604/biocell.2006.30.009

Abstract

In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cytotoxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations.

Keywords

Calotropis procera, Podophyllotoxin, cyclophosphamide, cytotoxic, Allium cepa

Cite This Article

SEHGAL,, R. (2006). Evaluation of cytotoxic potential of latex of Calotropis procera and Podophyllotoxin in Allum cepa root model. BIOCELL, 30(1), 9–13.

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This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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