WU LI1, JIANGZHE SI2, SHUAI QIU2, JING LUO1, HUIQIONG SUN1, XIAOQING LI1, ZHIBIN WAN1, WEI GAO1, HANLU ZOU1, LEI ZHANG2, XIAOHONG XIANG3, YANZHANG LI2, TIESHAN TENG2,*
BIOCELL, Vol.44, No.4, pp. 695-701, 2020, DOI:10.32604/biocell.2020.011941
Abstract The rapid emergence of multidrug-resistant and extensively drug-resistant Tuberculosis retrieved intense
interest in phage-based therapy. This old approach, which was abandoned in the west in the 1940s but is generating
renewed interest, has stimulated fresh research on mycobacteriophages and their lytic efficiency against their hosts.
GP30 is a novel protein of the mycobacteriophage CASbig with undiscovered function. In this study, we analyzed the
role of CASbig gp30 in the host Mycobacterium smegmatis. Overexpression of gp30 in the host led to reduced growth
in acidic medium and attenuated the intracellular survival rate of M. smegmatis inside the THP-1 macrophages,
which may… More >
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