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    Clinical Characteristics and Molecular Patterns of RET-Rearranged Lung Cancer in Chinese Patients

    Kai Zhang*, Huajun Chen, Ye Wang, Lin Yang§, Chengzhi Zhou, Weiqiang Yin#, Guangsuo Wang§, Xinru Mao**, Jianxing Xiang**, Bing Li**, Tengfei Zhang**, Shihong Fei*

    Oncology Research, Vol.27, No.5, pp. 575-582, 2019, DOI:10.3727/096504018X15344979253618

    Abstract RET rearrangement has been proven as an oncogenic driver in patients with lung cancer. However, the prevalence, clinical characteristics, molecular features, and therapeutic options in RET-rearranged patients remain unclear, especially in Chinese lung cancer patients. We retrospectively collected 6,125 Chinese lung cancer patients who have been profiled using next-generation sequencing (NGS). The clinical demographics and molecular features of RET rearrangement-positive patients were analyzed. RET rearrangements were identified in 84 patients with a proportion of 1.4% in our cohort. The median age at diagnosis was 58 years, and it mainly occurred in females with adenocarcinoma histology. KIF5B-RET was the most frequent… More >

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