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    3-Phosphoinositide Dependent Protein Kinase-1 (PDK-1) Promotes Migration and Invasion in Gastric Cancer Cells Through Activating the NF-κB Pathway

    Ning Wu*, Changyu He, Bohui Zhu*, Jinling Jiang, Yiwen Chen*, Tao Ma

    Oncology Research, Vol.25, No.7, pp. 1153-1159, 2017, DOI:10.3727/096504017X14845839228545

    Abstract Gastric cancer (GC) is one of the most common cancers and the second leading cause of cancer deaths in the world. Many factors have been reported regarding the progression and development of GC. In this study, we aimed to investigate the correlation of 3-phosphoinositide dependent protein kinase-1 (PDK-1) with cell viability, migration, and invasion of GC. The expression of PDK-1 was measured in different GC cell lines. Thereafter, the expression of PDK-1 was interfered by small hairpin RNA (shRNA) and then incubated with or without the inhibitor of nuclear factor-kB (NF-kB) pyrrolidine dithiocarbamate (PDTC). We… More >

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