Giacomo Iovane^1,*, Luca Traman², Michele Maffezzoli^1,3, Giuseppe Fornarini², Domenico Corradi⁴, Debora Guareschi⁴, Matteo Santoni^5,#, Sebastiano Buti^1,#

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070523 - 30 December 2025

Abstract Background: While the treatment of metastatic renal cell carcinoma (mRCC) is evolving due to immune checkpoint inhibitors (ICIs), optimal strategies for later lines of therapy have yet to be defined. The combination of lenvatinib and everolimus represents a viable option, and the present review aimed to summarize its activity, effectiveness, and safety. Methods: A systematic review of the literature was conducted using PubMed, targeting studies published between 2018 and 2025. Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen. Results:… More > Graphic Abstract

Xiaoyu Wen^1,2, Haohao Liu^1,2, Xinyu Zhang^1,2, Haoqi Wang^1,2, Yuyan Zhang^1,2, Guoyong Ye^1,2, Hongwen Xing³, Siren Liu³, Hao Li^1,2,*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-27, 2026, DOI:10.32604/cmc.2025.069492 - 10 November 2025

Abstract Aircraft assembly is characterized by stringent precedence constraints, limited resource availability, spatial restrictions, and a high degree of manual intervention. These factors lead to considerable variability in operator workloads and significantly increase the complexity of scheduling. To address this challenge, this study investigates the Aircraft Pulsating Assembly Line Scheduling Problem (APALSP) under skilled operator allocation, with the objective of minimizing assembly completion time. A mathematical model considering skilled operator allocation is developed, and a Q-Learning improved Particle Swarm Optimization algorithm (QLPSO) is proposed. In the algorithm design, a reverse scheduling strategy is adopted to effectively… More >

Luke Patrick O’Connor¹, Alexander Jordan Henry², Wendy Michelle Novicoff³, Marwan Ali², Adam Seth Baumgarten⁴, Nicolas Martin Ortiz^2,*

Canadian Journal of Urology, Vol.32, No.6, pp. 621-626, 2025, DOI:10.32604/cju.2025.065217 - 30 December 2025

Abstract Background: Postoperative pain management after penile prosthesis (PP) has traditionally required opioid medication. Recently, urologic prosthetic surgeons have sought to establish opioid-free protocols (OFP) and/or opioid-reduced protocols (ORP) for PP postoperative pain management. We sought to investigate the adoption patterns of OFP/ORP among surgeons who perform PP surgery and identify barriers to implementation. Methods: A 13-question confidential survey was sent to members of the Sexual Medicine Society of North America (SMSNA) and the Society of Urologic Prosthetic Surgeons (SUPS) via email. The survey was administered via Qualtrics. A t-test was used to analyze survey responses. Results:… More >

William Daly^*, Daniel Pelzman, P. Dafe Ogagan, Stephen V. Jackman

Canadian Journal of Urology, Vol.32, No.6, pp. 669-672, 2025, DOI:10.32604/cju.2025.063778 - 30 December 2025

Abstract Background: Minor bleeding after prostate biopsy is a relatively common complication, but clinically significant hemorrhage happens rarely. Management of prostatic artery pseudoaneurysm has not been described in the literature. Case Description: In this case, an 84-year-old man presented after prostate biopsy with rectal bleeding and required a massive transfusion. Ultimately, he was found to have a prostatic artery pseudoaneurysm, which to our knowledge is heretofore undescribed after prostate biopsy. Bleeding ultimately stopped spontaneously as the patient deferred angioembolization. He had not recurrent bleeding on follow up but is still deciding on treatment course for newly diagnosed More >

Minglei Hu¹, Wei Zhang¹, Bin Hu¹, Haicun Yang², Fuqiang Chu², Zheng Cao^2,*

Journal of Polymer Materials, Vol.42, No.4, pp. 1125-1141, 2025, DOI:10.32604/jpm.2025.073300 - 26 December 2025

Abstract Polypropylene (PP) has low inherent susceptibility to common industrial lasers, which poses a significant challenge for laser-based marking. To improve the laser sensitivity of PP, molybdenum disulfide grafted with polystyrene (MoS₂-g-PS) was synthesized via in-situ free radical polymerization and used as a laser-sensitive filler for PP composites prepared by melt blending. The composites were then marked with a 1064 nm semiconductor laser, producing clear and legible patterns. The marked surfaces were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), colorimetry, Raman spectroscopy, and thermogravimetric analysis (TGA). The results demonstrate that the PP/MoS₂-g-PS composites exhibit significantly More >

Shun Maki^1,*, Satoshi Nakano¹, Taiki Haga², Takehiro Niitsu¹, Ikuya Ueta¹

Congenital Heart Disease, Vol.20, No.5, pp. 547-558, 2025, DOI:10.32604/chd.2025.072277 - 30 November 2025

Abstract Background: Considering the limited evidence for acute postoperative nutritional therapy for congenital heart disease (CHD), this study evaluated the effects of achieving enteral nutrition (EN) targets in the acute postoperative phase on clinical outcomes in infants after congenital heart surgery. Methods: This retrospective cohort study, conducted in a multivalent pediatric intensive care unit (PICU), enrolled infants aged ≤6 months following congenital heart surgery between April 2021 and March 2023. Based on the American Society for Parenteral and Enteral Nutrition guidelines, the EN target was defined as two-thirds of the resting energy expenditure with a protein intake… More >

Si Qin, Shu Tang, Lijiao Xie, Jianbo Zhu, Jianguo Sun^*

Oncology Research, Vol.33, No.12, pp. 4145-4154, 2025, DOI:10.32604/or.2025.068300 - 27 November 2025

Abstract Background: Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype of primary non-small cell lung cancer (NSCLC), with no established treatment guidelines. We present a case of a young female with PPLELC who achieved a pathological complete response (pCR) in both primary and metastatic lesions after receiving combined immunotherapy and radiotherapy. Case description: We present a 33-year-old female patient with stage IVa (cT2bN0M1b) PPLELC. As a first-line treatment, the patient received seven cycles of nab-paclitaxel combined with toripalimab (a PD-1 inhibitor) and achieved stable disease. This was followed by toripalimab maintenance therapy for nearly 30 months.… More >

Xinyu Jiang¹, Chongrui Du¹, Yamin Wang², Honghua Dai^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.4, pp. 1-1, 2025, DOI:10.32604/icces.2025.011552

Abstract Persistent high-resolution observation of the solar corona is essential for advancing human’s understanding of critical solar phenomena, including coronal heating, solar wind acceleration, and the initiation of coronal mass ejections that significantly impact space weather. This study proposes a novel space-based solar corona observation mission concept, which uses a tethered solar sail spacecraft to create a sustained artificial total solar eclipse near the Sun-Earth L2 point. By positioning a probe at the end of Earth’s umbra cone and leveraging Earth as a natural occulter, the mission enables uninterrupted observations of the innermost solar corona. To… More >

Raidizon Mercedes, Eric Eidelman, Michael Mawhorter, Max Yudovich, Alireza Aminsharifi^*

Canadian Journal of Urology, Vol.32, No.5, pp. 515-520, 2025, DOI:10.32604/cju.2025.067973 - 30 October 2025

Abstract Background: Spontaneous rupture of the urinary bladder (SRUB) is a rare condition characterized by bladder rupture without any trauma or previous instrumentation. Diagnosing SRUB can be challenging, leading to potential delays in treatment and significant morbidity. Case description: We present a case of a 75-year-old male with a complex medical history, including atrial fibrillation, systemic lupus erythematosus, antiphospholipid syndrome, and chronic anticoagulation, who developed sudden onset gross hematuria and abdominal pain following bilateral internal iliac artery angioembolization for a spontaneous pelvic hematoma in the setting of supratherapeutic anticoagulation. Extraperitoneal bladder perforation was confirmed by CT cystogram.… More >

Zhiguang Zhang, Caisheng Wei, Guanhua Huang, Zeyang Yin^*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.3, pp. 1-1, 2025, DOI:10.32604/icces.2025.010967

Abstract An optimal predictive control method for spacecraft rendezvous based on Koopman operator is proposed for the the libration point rendezvous problem of Earth-moon system. Firstly, the relative motion dynamics model between the chaser and the target spacecraft in the Earth-moon system is established. Secondly, considering the influence of nonlinearity on spacecraft rendezvous control, a global linearization method of nonlinear rendezvous system driven by Koopman operator is proposed. In this method, the Koopman linearization operator is approximated by the extended dynamic mode decomposition (EDMD) method on the finite dimension. Subsequently, based on the linearization model of… More >