XING YE1,#, ZHOUTING TUO2,#, KAI CHEN3, RUICHENG WU3, JIE WANG3, QINGXIN YU4, LUXIA YE5, AKIRA MIYAMOTO6, KOO HAN YOO7, CHI ZHANG8, WURAN WEI3, DENGXIONG LI3,*, DECHAO FENG3,*
Oncology Research, Vol.32, No.3, pp. 503-515, 2024, DOI:10.32604/or.2024.045050
Abstract The increasing interest in RNA modifications has significantly advanced epigenomic and epitranscriptomic technologies. This study focuses on the immuno-oncological impact of ALYREF in human cancer through a pan-cancer analysis, enhancing understanding of this gene’s role in cancer. We observed differential ALYREF expression between tumor and normal samples, correlating strongly with prognosis in various cancers, particularly kidney renal papillary cell carcinoma (KIRP) and liver hepatocellular carcinoma (LIHC). ALYREF showed a negative correlation with most tumor-infiltrating cells in lung squamous cell carcinoma (LUSC) and lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), while positive correlations were noted in LIHC, kidney chromophobe (KICH), mesothelioma… More >
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