Sha Hu^1,2,#, Wenjing Wang^1,#, Qianfang Hu^3,#, Rujuan Zheng^1,2, Qinghe Huang^1,2, Hui Shi^1,2, Xinyuan Ding^3,*, Wenjuan Wang^1,2,*, Zengyan Zhu^1,2,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.068967 - 19 January 2026

Abstract Objectives: Acquired resistance to paclitaxel represents a critical barrier to the effective chemotherapy of non-small cell lung cancer (NSCLC). The present study aimed to elucidate the molecular and pharmacological mechanisms promoting paclitaxel resistance in NSCLC and to explore potential strategies for overcoming this resistance. Methods: Here, we report an integrated pharmacological and analytical approach to quantify paclitaxel disposition and overcome resistance in a A549/TAX cell model (paclitaxel-resistant A549 cells). Results: Cell counting kit-8 (CCK-8) assay, colony formation, and apoptosis assays confirmed that A549/TAX cells exhibited marked resistance to paclitaxel relative to parental A549 cells. Based on… More >

Xuekun Shao^1,#, Cheng Wang^2,#,*, Mengru Zhang², Yi Wang², Zhuoya Qiu¹, Wen Cai¹, Ruiliang Zhu³, Ping Wang^2,*

BIOCELL, Vol.49, No.11, pp. 2181-2194, 2025, DOI:10.32604/biocell.2025.070859 - 24 November 2025

Abstract Objectives: PI3K plays a pivotal role in the inflammatory response by modulating the production and release of inflammatory factors. Pik3cb is one of the subunits of PI3K, and its specific role in myocardium inflammation remains unelucidated. This study aimed to investigate the role of Pik3cb in the inflammatory response and to elucidate the underlying mechanism. Methods: An inflammation model was established using H9c2 cells treated with LPS and ATP, and Pik3cb expression was evaluated in this model system. Subsequently, an overexpression model was constructed by transfecting cells with a Pik3cb overexpression plasmid, after which the… More > Graphic Abstract

Li Yu^1,2,3, Xiaoyan Zhang^1,2, Yan Feng^1,4, Xinyue Liao^1,4, Tiejun Zhou⁵, Hang Si^1,4, Yun Feng^1,4, Decai Wang^6,*, Yongxian Lai^1,7,*

Oncology Research, Vol.33, No.8, pp. 2037-2053, 2025, DOI:10.32604/or.2025.064276 - 18 July 2025

Abstract Background: Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy with a low five-year survival rate. ATP-binding cassette subfamily B member 5 (ABCB5) has been linked to tumorigenesis. However, its role in inducing OSCC remains unclear. Methods: Quantitative reverse transcription polymerase chain reaction (qRT-PCR), western blot, and immunocytochemistry (ICC) were performed to examine the level of ABCB5 in OSCC (CAL27 and HSC-3) and human oral keratinocyte (HOK). ABCB5 was knocked down in CAL27 cells using ABCB5-specific small interfering RNA (ABCB5 siRNA), and its contribution to migration, invasion, and epithelial-mesenchymal transition (EMT),… More >

YA-LING YEH¹, YING-JAN WANG¹, SHOEI-YN LIN-SHIAU^2,3,*

Oncology Research, Vol.33, No.7, pp. 1781-1796, 2025, DOI:10.32604/or.2025.063717 - 26 June 2025

Abstract Background: The increasing incidence of cancers and infectious diseases worldwide presents a significant public health challenge that requires immediate intervention. Our strategy to tackle this issue involves the development of pharmaceutical formulations that combine phytopolyphenols (P), targeted drugs (T), and metal ions (M), collectively referred to as PTM regimens. The diverse pharmacological properties of PTM regimens are hypothesized to effectively reduce the risk factors associated with both cancers and infectious diseases. Methods: The effects of the pharmaceutical agents on the proliferation of cultured cancer cells and pathogens were assessed after 72 h and 48 h,… More >

EDMUND CHEUNG SO^1,2,#, LOUIS W. C. CHOW^3,#, CHIN-MIN CHUANG⁴, CING YU CHEN^5,6, CHENG-HSUN WU⁷, LIAN-RU SHIAO⁸, TING-TSZ OU⁹, KAR-LOK WONG¹⁰, YUK-MAN LEUNG^8,*, YI-PING HUANG^8,*

Oncology Research, Vol.33, No.2, pp. 397-406, 2025, DOI:10.32604/or.2024.052743 - 16 January 2025

Abstract Objectives: Mitochondrial Ca²⁺ uniporter (MCU) provides a Ca²⁺ influx pathway from the cytosol into the mitochondrial matrix and a moderate mitochondrial Ca²⁺ rise stimulates ATP production and cell growth. MCU is highly expressed in various cancer cells including breast cancer cells, thereby increasing the capacity of mitochondrial Ca²⁺ uptake, ATP production, and cancer cell proliferation. The objective of this study was to examine MCU inhibition as an anti-cancer mechanism. Methods: The effects of MCU-i4, a newly developed MCU inhibitor, on cell viability, apoptosis, cytosolic Ca²⁺, mitochondrial Ca²⁺ and potential, glycolytic rate, generation of ATP, and reactive oxygen species,… More >

Olanrewaju M. Oyewola^1,*, Olawale S. Ismail², Adetokunbo A. Awonusi²

Frontiers in Heat and Mass Transfer, Vol.22, No.2, pp. 475-490, 2024, DOI:10.32604/fhmt.2024.047714 - 20 May 2024

Abstract One of the new methods for ensuring that the battery in a thermal energy storage system is kept at the proper temperature is the heat pipe-based Thermal Management System (TMS). In this study, the improvement of cooling performance of a heat pipe based TMS is examined through the variation of condenser section length of heat pipes in an array. The TMSs with an array of heat pipes with different condenser section lengths are considered. The system performances are evaluated using a validated numerical method. The results show that a heat pipe-based TMS provides the best More >

SHAHID KARIM^1,*, ALANOUD NAHER ALGHANMI¹, MAHA JAMAL¹, HUDA ALKREATHY¹, ALAM JAMAL², HIND A. ALKHATABI³, MOHAMMED BAZUHAIR¹, AFTAB AHMAD^4,5

Oncology Research, Vol.32, No.5, pp. 817-830, 2024, DOI:10.32604/or.2024.048988 - 23 April 2024

Abstract Cancer frequently develops resistance to the majority of chemotherapy treatments. This study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors, specifically Canagliflozin (CAN), Dapagliflozin (DAP), Empagliflozin (EMP), and Doxorubicin (DOX), using in vitro experimentation. The precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin (DOX) in MCF-7 cells. Interestingly, it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their growth. Notably, when these medications were combined with DOX, there was a considerable inhibition of glucose consumption, as More > Graphic Abstract

Sophea Horng, Pisal Yenradee^*

CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 6119-6143, 2023, DOI:10.32604/cmc.2023.038764 - 29 April 2023

Abstract This paper proposes a Delivery Service Management (DSM) system for Small and Medium Enterprises (SMEs) that own a delivery fleet of pickup trucks to manage Business-to-Business (B2B) delivery services. The proposed DSM system integrates four systems: Delivery Location Positioning (DLP), Delivery Route Planning (DRP), Arrival Time Prediction (ATP), and Communication and Data Sharing (CDS) systems. These systems are used to pinpoint the delivery locations of customers, plan the delivery route of each truck, predict arrival time (with an interval) at each delivery location, and communicate and share information among stakeholders, respectively. The DSM system deploys… More >

Emad Abd Al Rahman¹, Nur Intan Raihana Ruhaiyem^1,*, Majed Bouchahma², Kamarul Imran Musa³

Intelligent Automation & Soft Computing, Vol.36, No.3, pp. 3007-3028, 2023, DOI:10.32604/iasc.2023.032580 - 15 March 2023

Abstract This study offers a framework for a breast cancer computer-aided treatment prediction (CATP) system. The rising death rate among women due to breast cancer is a worldwide health concern that can only be addressed by early diagnosis and frequent screening. Mammography has been the most utilized breast imaging technique to date. Radiologists have begun to use computer-aided detection and diagnosis (CAD) systems to improve the accuracy of breast cancer diagnosis by minimizing human errors. Despite the progress of artificial intelligence (AI) in the medical field, this study indicates that systems that can anticipate a treatment… More >

Raed Alhamad^1,*, Hatem Boujemaa²

Computer Systems Science and Engineering, Vol.45, No.2, pp. 2059-2070, 2023, DOI:10.32604/csse.2023.032610 - 03 November 2022

Abstract In this article, we use Intelligent Reflecting Surfaces (IRS) to improve the throughput of Non Orthogonal Multiple Access (NOMA) with Adaptive Transmit Power (ATP). The results are valid for Cognitive Radio Networks (CRN) where secondary source adapts its power to generate low interference at primary receiver. In all previous studies, IRS were implemented with fixed transmit power and previous results are not valid when the power of the secondary source is adaptive. In CRN, secondary nodes are allowed to transmit over the same band as primary users since they adapt their power to minimize the More >