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  • Open Access

    ARTICLE

    Crazy Rotating: The Linear or Curvilinear Relationship of Parental Overparenting and Adolescent Internalizing Problems in China

    Qiaoer Li#, Xiaoting Hou#, Jingjing Zhao, Shufen Xing*

    International Journal of Mental Health Promotion, Vol.28, No.5, 2026, DOI:10.32604/ijmhp.2026.074860 - 28 May 2026

    Abstract Background: Parental overparenting is highly prevalent in current Chinese families, and its psychological influences on adolescent mental health are of great academic and practical concern. However, limited research has examined the potential curvilinear relationship between different dimensions of parental overparenting and adolescent internalizing problems, as well as the moderating roles of adolescent gender and age in these relationships. The purpose of this study was to examine the unique and potentially curvilinear effects of different dimensions of parental overparenting on adolescent internalizing problems in the context of contemporary Chinese families. Methods: Data were collected from 285 adolescents… More >

  • Open Access

    ARTICLE

    Interpretable Cox-Guided Risk Stratification for Specialized Expert Learning in Pan-Cancer Survival Prediction

    Manal Mohammed AL-Tamimi1,2,*, Siti Norul Huda Sheikh Abdullah1,*, Mohammad Khatim Hasan1, Mohammed Azmi Al-Betar3,4, Maw Shin Sim5, Abdulrahman Mohammed AL-Tamimi1

    CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.2, 2026, DOI:10.32604/cmes.2026.079891 - 27 May 2026

    Abstract Pan-cancer survival prediction remains a major challenge in personalized oncology due to profound tumor heterogeneity and the complexity of high-dimensional molecular data. Diverse risk profiles across cancer types and noisy, sparse features hinder deep learning models from capturing robust prognostic patterns. Prior pan-cancer studies predominantly focus on multimodal integration or unimodal gene expression analysis, leaving other informative modalities such as Copy Number Variation (CNV) and miRNA expression underexplored. We introduce a new formulation of mixture-of-experts (MoE) survival modeling that recasts expert assignment as a clinically interpretable risk-space decomposition problem. The proposed framework, CoxGuided-SE, constructs an… More >

  • Open Access

    ARTICLE

    Alleviation of Salt Stress on the Growth and Active Constituents of Chamomile (Matricaria chamomilla L.) Using Glutathione and Hydrogen Peroxide

    Wessam M. Serag El-Din1,*, Kamal E. Attia1, Taghreed E. Eissa2,*, Tarek M. Noor El-Deen2, Hadeer Darwish1,3, Ghadah H. Al Hawas4,5, Modhi O. Alotaibi6,7

    Phyton-International Journal of Experimental Botany, Vol.95, No.5, 2026, DOI:10.32604/phyton.2026.078357 - 27 May 2026

    Abstract Water salinity is a growing environmental concern that significantly impacts soil health, agricultural productivity, and freshwater sustainability, especially in arid regions. This study evaluated the comparative effects of foliar-applied glutathione (GSH) and hydrogen peroxide (H2O2) on growth, flower yield, essential oil composition, and physiological responses of Matricaria chamomilla L. under water salinity levels. The experiment was conducted during the 2022/2023 and 2023/2024 seasons at the Experimental Farm of El-Quassassin, Ismailia, Egypt, using a factorial randomized complete block design with three replicates. Foliar applications of GSH (1, 2, and 3 mM) and H2O2 (5, 10, and 20 mM)… More >

  • Open Access

    REVIEW

    EZH2 in Acral Lentiginous Melanoma: Molecular, Epigenetic, and Therapeutic Perspectives

    Daniel Arcuschin de Oliveira1, Melissa Yoshimi Sakamoto Maeda Nisimoto1, Jaciara Moreira Sodré Hunnicutt1, Eduarda Massa Sartori1, Amanda Fáris Marques1, Francisco Macedo Paschoal2, Luciana Cavalheiro Marti1,3, Miriam Galvonas Jasiulionis4, Miguel Sabino Neto1, Renato Santos de Oliveira Filho1,*

    Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.077913 - 21 May 2026

    Abstract Acral lentiginous melanoma (ALM) is characterized by a low mutational burden, frequent chromosomal rearrangements, and profound epigenetic dysregulation, distinguishing it from ultraviolet (UV)-induced melanoma. Among the epigenetic regulators, Enhancer of Zeste Homolog 2 (EZH2), the catalytic component of the Polycomb Repressive Complex 2 (PRC2), plays a central role in chromatin compaction and transcriptional repression through trimethylation of histone H3 on lysine 27 (H3K27me3). EZH2 overexpression or hyperactivation contributes to tumor progression, immune evasion, and therapeutic resistance. Recent multi-omic studies have highlighted the importance of EZH2 in regulating melanoma plasticity, immune modulation, and metabolic reprogramming. In… More > Graphic Abstract

    EZH2 in Acral Lentiginous Melanoma: Molecular, Epigenetic, and Therapeutic Perspectives

  • Open Access

    ARTICLE

    An Unpaired Dual-Domain Image Dehazing Framework Using Unsupervised Learning

    Shunpeng Yang1, Yunpeng Wu1, Wenwen Qin1, Cheng Yang2,*, Yu Qian3

    Structural Durability & Health Monitoring, Vol.20, No.3, 2026, DOI:10.32604/sdhm.2026.077878 - 18 May 2026

    Abstract To enhance traffic infrastructure health monitoring via computer vision (CV) in adverse weather conditions, image dehazing has emerged as a critical processing step. However, current supervised dehazing models, typically trained on synthetic hazy-clean image pairs, often demonstrate limited generalization ability when deployed in real-world haze scenarios. This study proposes a novel unsupervised dehazing framework named the unpaired dual-domain dehazing network (UD3Net). Initially, a novel dual-domain convolutional mixer (DCM) is developed, which can extract local features in the spatial domain and global features in the frequency domain to achieve thorough information fusion, aiming to facilitate accurate estimation… More >

  • Open Access

    ARTICLE

    From Stress Redistribution to Energy Accumulation: Lateral Pressure-Driven Chain Evolution in Gas-Bearing Coal

    Wenqi Zheng1,2,3, Feng Gao4, Hanpeng Wang1,2,3,*, Xin Wang1,2,3, Bing Zhang1,2,3, Yue Niu4, Wei Wang1,2,3, Li Ming5, Chunbo Zhou6,*

    FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.4, 2026, DOI:10.32604/fdmp.2026.079913 - 07 May 2026

    Abstract As coal extraction advances to greater depths, a refined understanding of the coupled evolution of involved physical effects and mechanisms in gas-bearing coal under excavation-induced disturbances becomes indispensable. In this context, “chain evolution” characterizes the progressive and interdependent interplay among stress redistribution, damage propagation, and seepage adjustment. Building upon a seepage–stress–damage coupling model for gas-bearing coal, and supported by triaxial compression tests for validation, this study explores multifield evolution during roadway excavation across lateral pressure coefficients ξ of 0.5, 0.8, 1.0, 1.2, and 1.5. The results reveal that the lateral pressure… More >

  • Open Access

    ARTICLE

    Effects of Paclobutrazol Application Methods and Dosages on the Growth, Morphological Characteristics, and Color Quality of Silene compacta Fisch.

    Selma Kösa*

    Phyton-International Journal of Experimental Botany, Vol.95, No.4, 2026, DOI:10.32604/phyton.2026.079055 - 28 April 2026

    Abstract This study was conducted to determine the effects of paclobutrazol (PBZ) application methods and dosages on the growth, leaf, flower, and color characteristics of Silene compacta Fisch., a natural species with high potential for use as a seasonal bedding and potted ornamental plant in landscape design. The experiment was carried out under greenhouse conditions, where potted plants received a single PBZ application during the vegetative stage. The study was arranged in a completely randomized design with a 2 × 3 factorial structure. PBZ was applied either as a foliar spray or as a soil drench at… More >

  • Open Access

    ARTICLE

    Mebendazole Attenuates Cellular Invasion in a 3D Culture Model of Meningioma by Disrupting Rho-GTPase-Mediated Microtubule Function

    Munro Matthew James1,*, López Vásquez Clara Elena1,2, Wickremesekera Agadha3, Chan Alex Ho Chuen1, Gray Clint Lee1,4,5,*

    Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.074958 - 22 April 2026

    Abstract Objective: Meningioma is the most common primary brain tumour. Invasion into the brain is a diagnostic feature of grade II meningiomas and is associated with recurrence and poor prognosis. Mebendazole is a microtubule inhibitor typically prescribed as an anthelmintic. However, it has the potential to be repurposed for cancer treatment. Here, we aimed to assess the ability of mebendazole to inhibit meningioma cell invasion. Methods: Primary patient-derived meningioma cell lines were cultured as 3D spheroids and embedded in an extracellular matrix-like matrix as an in vitro model of invasion. Mebendazole-treated and untreated control spheroids were analysed… More >

  • Open Access

    ARTICLE

    Numerical Simulations of Extreme Deformation Problems in Granular-Dominated Hazard from Indoor to Engineering Geological Scale: A Comparative Study

    Yuxin Tian1, Wangxin Yu1, Wanqing Yuan1, Qingquan Liu1,*, Xiaoliang Wang1,2,3,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.3, 2026, DOI:10.32604/cmes.2026.078776 - 30 March 2026

    Abstract Granular flow, such as hopper discharge and debris flows, involves complex multi-scale, multi-phase, and multi-physics coupling, posing significant challenges for numerical simulation. Over the past two decades, methods like the Discrete Element Method (DEM), Smoothed Particle Hydrodynamics (SPH), and Depth-Averaging Method (DAM), have been developed to address these problems. However, their applicability across different scales remains unclear due to differences in physical assumptions and numerical algorithms. Therefore, a comprehensive evaluation is critically needed. This study selects three typical methods (DEM, SPH, and DAM) to examine their convergence behavior, boundary condition implementation, and limitations in physical More >

  • Open Access

    ARTICLE

    Discovery of Two Novel Pyrazole Derivatives as Anticancer Agents Targeting Tubulin Polymerization and MAPK Signaling Pathways

    Denisse A. Gutierrez*, Elisa Robles-Escajeda, Jose A. Lopez-Saenz, Robert A. Kirken, Edgar A. Borrego, Ana P. Betancourt, Soumya Nair, Sourav Roy, Armando Varela-Ramirez, Renato J. Aguilera*

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074945 - 23 March 2026

    Abstract Objectives: Drug resistance is the major determinant of chemotherapy failure, leading to relapse and tumor progression, demonstrating the urgent need for novel antineoplastic drugs. This study aimed to evaluate the anticancer potential of two novel pyrazole derivatives, P3C.1 and P3C.2, and to elucidate their mechanism of action in cancer cells. Methods: The cytotoxicity of the compounds was evaluated across 27 different cancer cell lines via a nuclear staining assay. Subsequent flow cytometric and biochemical analyses were performed to assess reactive oxygen species (ROS) generation, apoptosis induction, mitochondrial integrity, and cell cycle progression. Additional studies included… More >

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