Jiang-Nan Xia^#, Shan-Dong Zhu^#, Wei-Ling Qu, Yi-Lin Hu, Wen-Yi Ma, Wenyan Wang, Qian-Lan Huang, Bing-Yuan Lin, Jia-En Guo, Ying-Wei Li^*

Oncology Research, Vol.34, No.10, 2026, DOI:10.32604/or.2026.084576 - 14 September 2026

Abstract Objectives: As an aggressive subtype of breast cancer, triple-negative breast cancer (TNBC) is constrained by the limited availability of effective treatments and the absence of well-validated therapeutic targets. This study aimed to explore whether honokiol, a potent YAP/TAZ inhibitor, suppresses stem cell–like properties and enhances chemotherapeutic efficacy in TNBC by blocking YAP/TAZ–TEAD transcriptional complex. Methods: Through both in vitro and in vivo models of TNBC, the current study examined how honokiol influences cell proliferation, cancer stem cell (CSC) traits, and paclitaxel sensitivity. To uncover the molecular mechanisms, we analyzed the transcript levels and protein abundance of core YAP/TAZ–TEAD… More >

Chao Mi^1,*, Shimeng Li¹, Xuetao Yang², Jinxiong Wang^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.8, 2026, DOI:10.32604/phyton.2026.085115 - 28 August 2026

Abstract Rapeseed (Brassica rapa L.) is the primary oil crop in Xizang. However, its loosely branched structure hinders mechanical harvesting. Improvement in plant architecture is necessary to align with industrial development; however, research on branch angle in rapeseed is limited. The branch angle of compact plant type (S) was smaller than that of the dispersed plant type (F). RNA sequencing and targeted metabolome analyses of branch angles of both plant types were assessed at different branch sites. In the S plant type, IAA (3-Indoleacetic acid) contents were significantly higher than those in F at the five stem… More >

Xue Yang¹, Shunpeng Yang¹, Wanying Shi^2,*, Weizhong Yuan¹, Sihui Long¹, Ruixiao Sun³, Cheng Yang⁴

Structural Durability & Health Monitoring, Vol.20, No.5, 2026, DOI:10.32604/sdhm.2026.078468 - 24 August 2026

Abstract Unmanned aerial vehicle (UAV) imaging techniques have emerged as a promising solution to boost the accuracy and dependability of visual monitoring for railway facilities and peripheral ecological environments, garnering widespread research interest in recent years. Nevertheless, aerial images acquired by UAVs are prone to severe quality deterioration in fog and haze weather scenarios, which greatly hinders the progress and effectiveness of railway routine inspection work. As modern railway systems pursue higher operational safety benchmarks and intelligent rail transit technologies achieve iterative breakthroughs, video monitoring systems have evolved into indispensable core equipment for identifying and early… More >

Aigerim Altayeva^1,*, Nurzhan Omarov²

CMC-Computers, Materials & Continua, Vol.89, No.1, 2026, DOI:10.32604/cmc.2026.080878 - 13 August 2026

Abstract Hazardous impulsive sound detection plays a critical role in intelligent surveillance, public safety monitoring, and automated emergency response systems. This study proposes a lightweight channel-attention-enhanced deep learning architecture for real-time detection and classification of hazardous acoustic events. The proposed framework utilizes mel-spectrogram representations to capture time-frequency characteristics of audio signals and employs a compact convolutional neural backbone to efficiently extract hierarchical features. To enhance feature discrimination, a squeeze-and-excitation channel-attention mechanism is integrated into the architecture, enabling adaptive recalibration of feature channels and improved robustness under noisy and complex acoustic environments. A custom dataset consisting of More >

Antonio Pizzi^*

Journal of Renewable Materials, Vol.14, No.7, 2026, DOI:10.32604/jrm.2026.02026-0056 - 28 July 2026

Abstract Cross Polarization Magic Angle Spinning Carbon 13 Nuclear Magnetic Resonance (CP-MAS ¹³C NMR) analysis of commercial procyanidin (pine bark) and delphinidin (pecan nut membranes) condensed flavonoid tannin extracts reacted with hexamethylenetetramine (hexamine) have shown that due to the highly reactive imino-amino methylene species formed before its degradation reaches the generation of formaldehyde, benzylamine bridges between the flavonoid units are formed. This study shows that tannin-based biobenzoxazines are also generated at the same time, with both benzylamines and benzoxazines bridges being in more marked proportions, the more reactive the tannin reacted with hexamethylenetetramine is. This is not More > Graphic Abstract

Beatrice Sani^1,2, Alessandro Cignetti², Marta Leporati³, Sara Sommariva⁴, Marco Armenio¹, Valerio Tenace⁵, Arianna Savi², Johanna Umurungi^1,2, Giovanni Fornari^1,2, Simone Busso³, Alessandra Canevaro³, Igor Bisognin³, Silvia Marini¹, Michele Piana⁴, Daniela Cilloni^1,2, Valentina Gaidano^2,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.078245 - 16 July 2026

Abstract Objectives: Venetoclax (VEN) is approved for acute myeloid leukemia (AML) in association with azacitidine, in a 28-day schedule at a fixed dosage, which requires reduction if azoles are co-administered. The present study aims to evaluate VEN therapeutic drug monitoring (TDM) in a real-word setting, where the VEN schedule is frequently reduced, investigating: (i) the posaconazole impact, and (ii) whether VEN exposure correlates with safety and efficacy. Methods: We analyzed data from 43 AML patients treated with different VEN-containing regimens, for whom a near-trough VEN plasma concentration (Cmin) was determined at different timepoints (days 5-8-11-15-22-29) across different cycles… More >

Hsing-Ju Wu^1,2, Yu-Chieh Tsai^3,*, Hung-Yu Lin^2,4,*

European Cytokine Network, Vol.37, No.2, pp. 121-135, 2026, DOI:10.32604/ecn.2026.079012 - 30 June 2026

Abstract Backgrounds: Lymph node metastasis is a critical determinant of breast cancer prognosis, yet the specific microenvironmental cytokines driving this process remain elusive. This study aims to identify key prognostic cytokines linking nodal metastasis to tumor microenvironment (TME) remodeling and to evaluate their clinical utility. Methods: A predefined panel of 176 microenvironmental genes was evaluated using differential expression analysis and the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm on the TCGA-BRCA cohort to identify optimal predictors of nodal metastasis. Prognostic value was assessed via Kaplan-Meier, subgroup, and multivariate Cox regression analyses, and validated across five… More > Graphic Abstract

Jerome Gacu^1,2,*, Dencel Edrian Cawaling¹, Edel Queen Fiestada¹, Diablell Maybanting¹, Jamica Bensurto¹, John Kevin Falogme¹, Jea Janelle Fontamillas¹, Janellene Edd Gadon¹, Samaica Fernandez¹, Maryjay Sagario³

Revue Internationale de Géomatique, Vol.35, pp. 373-407, 2026, DOI:10.32604/rig.2026.083180 - 18 June 2026

Abstract A landslide is the downslope movement of soil, rock, or debris driven by gravity, often triggered by natural or anthropogenic factors. The Philippines is highly susceptible to landslides due to its steep terrain, frequent typhoons, intense rainfall, and seismic activity, resulting in significant socioeconomic and environmental impacts. Despite increasing landslide occurrences in vulnerable coastal and mountainous municipalities in the Philippines, localized and integrated Geographic Information System (GIS)-based landslide risk assessments incorporating hazard, vulnerability, and exposure components remain limited in small island municipalities such as San Andres, Romblon. This study assesses landslide risk in the Municipality… More >

Chiara Ferraro¹, Michela Pizzoferrato¹, Michela Graziano¹, Tiziana Servidei², Antonio Ruggiero², Pierluigi Navarra¹, Lucia Lisi^1,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.071074 - 16 June 2026

Abstract Objectives: Advances in molecular profiling of pediatric low-grade glioma have enabled targeted therapies to emerge as effective and better-tolerated alternatives to conventional chemotherapy, increasingly used in progressive or recurrent disease and may reduce long-term treatment toxicity. This study aimed to evaluate the repositioning of the anthelmintic drug mebendazole (MBZ) as an antiproliferative agent in pediatric glioma models, and to investigate potential synergistic effects in combination with vinblastine. Methods: Two well-established human pediatric glioma cell lines, RES 259 and RES 186, were exposed to MBZ alone or in combination with vinblastine. Cell viability, cytotoxicity, and tumor invasiveness… More >

Junming Yan, Boran Xiong, Yingjie Zhu^*

BIOCELL, Vol.50, No.6, 2026, DOI:10.32604/biocell.2026.075319 - 09 June 2026

Abstract Objective: Neural stem cells (NSCs) are essential for replenishing nerve cells, providing neuroprotection, and repairing damaged brain function, while mitophagy is critical for maintaining NSCs’ homeostasis. The study investigated whether pyruvate kinase M2 (PKM2) regulates NSCs’ proliferation and differentiation by modulating mitophagy. Method: This study established a model of excessive autophagy in neural stem cell mitochondria induced by cobalt chloride (CoCl₂) and used plasmid transfection technology to knock down PKM2 expression, examining its effects on NSCs proliferation and differentiation. Additionally, potential mechanisms were explored by overexpressing phosphatase and tensin homolog-induced putative kinase 1 (PINK1) and adding the… More > Graphic Abstract