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  • Open Access

    REVIEW

    A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

    NILAM BHUSARE, MAUSHMI KUMAR*

    Oncology Research, Vol.32, No.5, pp. 849-875, 2024, DOI:10.32604/or.2024.047042

    Abstract Glioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12–15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the presence of the blood-brain barrier and multidrug resistance mechanisms. Consequently, considerable research efforts have been directed toward understanding the underlying signaling pathways involved in glioma and developing… More > Graphic Abstract

    A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

  • Open Access

    ARTICLE

    The Lambert-G Family: Properties, Inference, and Applications

    Jamal N. Al Abbasi1, Ahmed Z. Afify2,*, Badr Alnssyan3,*, Mustafa S. Shama4,5

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 513-536, 2024, DOI:10.32604/cmes.2024.046533

    Abstract This study proposes a new flexible family of distributions called the Lambert-G family. The Lambert family is very flexible and exhibits desirable properties. Its three-parameter special sub-models provide all significant monotonic and non-monotonic failure rates. A special sub-model of the Lambert family called the Lambert-Lomax (LL) distribution is investigated. General expressions for the LL statistical properties are established. Characterizations of the LL distribution are addressed mathematically based on its hazard function. The estimation of the LL parameters is discussed using six estimation methods. The performance of this estimation method is explored through simulation experiments. The usefulness and flexibility of the… More >

  • Open Access

    ARTICLE

    Effect of Synthesis Parameters on Phosphoric Acid Doped Polybenzimidazole Membranes: A Parametric Evaluation from Microstructural Level to Fuel Cell Performance

    ÇAĞLA GÜL GÜLDİKEN, LEVENT AKYALÇIN, HASAN FERDİ GERÇEL*

    Journal of Polymer Materials, Vol.36, No.4, pp. 337-349, 2019, DOI:10.32381/JPM.2019.36.04.4

    Abstract In the present study, polybenzimidazole (PBI) polymer which has a great importance in polymer electrolyte membrane (PEM) research was synthesized via the solution polycondensation method, under various synthesis conditions to put forward the effect of the synthesis parameters on the properties of the synthesized polymer and consequently to the quality of the prepared polymer electrolyte membrane. The synthesized polymers were characterized in terms of their chemical structure, thermal degradation behaviour, and molecular weight by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (1 H NMR), thermogravimetric analysis (TGA). The Mechanical properties, acid-doping level capacity, proton conductivity, and fuel cell… More >

  • Open Access

    ARTICLE

    Robust Color Fastness of Dyed Silk Fibroin Film By Coupling Modification Dyeing with Aniline Diazonium Salt

    ZONGQIAN WANG, HAIWEI YANG, JIAN XING, ZHI LIU*

    Journal of Polymer Materials, Vol.36, No.2, pp. 149-159, 2019, DOI:10.32381/JPM.2019.36.02.4

    Abstract Colored silk fibroin (SF) film can change the proportion of transmitted light composition and therefore shows potential application in optoelectronics area. However, few methods are reported for the preparation of colored SF film with good color fastness. Herein, colored SF film was prepared by coupling modification dyeing (CM-dyeing) of SF tyrosine residues in solution. SF film shows excellent color fastness due to the formation of the azo covalent bond formed by electrophilic substitution reaction between SF tyrosine residues and aniline diazonium salt. Furthermore, compared with the undyed film, the dyed SF film is effectively preserved its mechanical property by the… More >

  • Open Access

    ARTICLE

    Renewable Bis-benzoxazine Monomers from Lignin Derivatives: Synthesis, Characterization and Studies on Curing Behavior

    CHUNYAN LIU*, YUNHE LIU, ZIHAN PAN, QIUTING LI, HAN XU, TAO LIU

    Journal of Polymer Materials, Vol.36, No.1, pp. 87-99, 2019, DOI:10.32381/JPM.2019.36.01.7

    Abstract In this work, a series of novel lignin-based bis-benzoxazine monomers were efficiently synthesized by the reaction of renewable phenols: guaiacol, vanillyl alcohol, eugenol, vanillin with ethylene diamine and paraformaldehyde. The chemical structures of these lignin-based bis-benzoxazine monomers were confirmed by 1H-NMR, 13C-NMR and FTIR, indicating the formation of benzoxazine ring. The obtained bis-benzoxazine monomers were cured via thermal treatment. The curing behavior of these lignin-based bis-benzoxazine monomers were compared and analyzed via differential scanning calorimetry (DSC), showing that Va-e possessed higher ring-opening polymerization activity than G-e, while E-e and V-e had lower curing activity than G-e. More >

  • Open Access

    ARTICLE

    Synthesis and Characterization of New Chromophore 4-2-(2-hydroxy-5-(4 nitrophenyl) diazenyl) benzylidene) hydrazinyl) Benzoic Acid and its use in Chitosan Modification

    KAZIM SHAMIM RIZVI, P.K.DUTTA*

    Journal of Polymer Materials, Vol.36, No.1, pp. 75-85, 2019, DOI:10.32381/JPM.2019.36.01.6

    Abstract The present investigation deals with the preparation of carboxylic acid containing new chromophore : 4-2-(2-hydroxy-5-(4-nitrophenyl) diazenyl) benzylidene) hydrazinyl) benzoic acid and its use for chemical modification of chitosan, e.g., chitosan-acid salt complexes under mild conditions. Optical properties of chitosan acid complexes were evaluated by UV and SHG spectroscopy which showed red shift. Antibacterial activity of prepared chitosan acid complexes showed obvious effect against food pathogenic bacteria. The novel polymer complex was soluble in most of the organic solvents. More >

  • Open Access

    ARTICLE

    Reinforcing Effect of Compatibilizers Containing Oxazoline Groups in Liquid Crystalline Polymer/ Polypropylene Blending Material

    SHOGO TAKASUKA1,*, TATSUHIRO TAKAHASHI1

    Journal of Polymer Materials, Vol.38, No.1-2, pp. 1-10, 2021, DOI:10.32381/JPM.2021.38.1-2.1

    Abstract The effects of compounds containing oxazoline groups and the presence of maleic anhydridegrafted polypropylene (PP-g-MAH) on the spectral, morphological, and tensile properties of polypropylene (PP)/liquid crystalline polymer (LCP) blends were investigated. A wholly aromatic LCP having a low melting point which was copolyester, namely AL-7000 have been used, because thermal decomposition of PP and compatibilizer must be prevented.Compression molding was selected as the molding method because it allows molding with a small amount of sample. The binary blends of PP and LCP showed a degradation of tensile properties compared to pure PP. However, the addition of 2,2'-bis(2-oxazoline) and PP-g-MAH as… More >

  • Open Access

    ARTICLE

    Synthesis and Characterization of poly (N-glycidyl-2- oxazolidone) Using a Green and Efficient Catalyst

    SORAYA SEGHIER1,2,*, MOHAMMED BELBACHIR1

    Journal of Polymer Materials, Vol.38, No.3-4, pp. 205-218, 2021, DOI:10.32381/JPM.2021.38.3-4.3

    Abstract In the present paper, we report the synthesis of a new amino polymer made of oxazolidinone using an efficient ecocatalyst called Maghnite-H+. The synthesis process contains two steps: the first consists to the preparation of an amino oxiran 3-(oxiran-ylmethyl) oxazolidin- 2-one (OMO) by a substitution reaction of epichlorhydrin by 2-oxazolidinone, the second step concerns a green polymerization of the resultant oxiran by a ring opening reaction catalysed by Maghnite-H+. The polymer have been successfully prepared and characterized by various techniques, such as 1H NMR, 13C NMR, IR, which were used to elucidate the structural characteristics of the resulting polymers. The… More >

  • Open Access

    ARTICLE

    Effect of Tetramethylurea (TMU) on Polysulfone Membrane Performance for Atrazine-containing Wastewater Treatment

    NIKITA GUPTA, SARITA KALLA, Z.V.P. MURTHY*

    Journal of Polymer Materials, Vol.40, No.3-4, pp. 317-328, 2023, DOI:10.32381/JPM.2023.40.3-4.12

    Abstract Tetramethylurea (TMU) is a good solvent for organic substances and has received little attention as compared to other solvents. The TMU is a polar solution and is one of the molecules with an amphiphilic character. In the present work, an attempt has been made to use TMU as an additive in the preparation of nanofiltration membranes to improve the hydrophilicity of the membrane. The polysulfone membrane has been modified by incorporating different concentrations of TMU (0, 0.5, and 1 wt.%) in order to check the rejection of atrazine in water. This study aim is to optimize the conditions to enhance… More >

  • Open Access

    ARTICLE

    CL2ES-KDBC: A Novel Covariance Embedded Selection Based on Kernel Distributed Bayes Classifier for Detection of Cyber-Attacks in IoT Systems

    Talal Albalawi, P. Ganeshkumar*

    CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3511-3528, 2024, DOI:10.32604/cmc.2024.046396

    Abstract The Internet of Things (IoT) is a growing technology that allows the sharing of data with other devices across wireless networks. Specifically, IoT systems are vulnerable to cyberattacks due to its opennes The proposed work intends to implement a new security framework for detecting the most specific and harmful intrusions in IoT networks. In this framework, a Covariance Linear Learning Embedding Selection (CL2ES) methodology is used at first to extract the features highly associated with the IoT intrusions. Then, the Kernel Distributed Bayes Classifier (KDBC) is created to forecast attacks based on the probability distribution value precisely. In addition, a… More >

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