Yuxin Tian¹, Wangxin Yu¹, Wanqing Yuan¹, Qingquan Liu^1,*, Xiaoliang Wang^1,2,3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.3, 2026, DOI:10.32604/cmes.2026.078776 - 30 March 2026

Abstract Granular flow, such as hopper discharge and debris flows, involves complex multi-scale, multi-phase, and multi-physics coupling, posing significant challenges for numerical simulation. Over the past two decades, methods like the Discrete Element Method (DEM), Smoothed Particle Hydrodynamics (SPH), and Depth-Averaging Method (DAM), have been developed to address these problems. However, their applicability across different scales remains unclear due to differences in physical assumptions and numerical algorithms. Therefore, a comprehensive evaluation is critically needed. This study selects three typical methods (DEM, SPH, and DAM) to examine their convergence behavior, boundary condition implementation, and limitations in physical More >

Denisse A. Gutierrez^*, Elisa Robles-Escajeda, Jose A. Lopez-Saenz, Robert A. Kirken, Edgar A. Borrego, Ana P. Betancourt, Soumya Nair, Sourav Roy, Armando Varela-Ramirez, Renato J. Aguilera^*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074945 - 23 March 2026

Abstract Objectives: Drug resistance is the major determinant of chemotherapy failure, leading to relapse and tumor progression, demonstrating the urgent need for novel antineoplastic drugs. This study aimed to evaluate the anticancer potential of two novel pyrazole derivatives, P3C.1 and P3C.2, and to elucidate their mechanism of action in cancer cells. Methods: The cytotoxicity of the compounds was evaluated across 27 different cancer cell lines via a nuclear staining assay. Subsequent flow cytometric and biochemical analyses were performed to assess reactive oxygen species (ROS) generation, apoptosis induction, mitochondrial integrity, and cell cycle progression. Additional studies included… More >

Chang He^#, An Wang^#, Youbo Wang^#, Qinyun Ma^*, Xiaofeng Chen^*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074880 - 23 March 2026

Abstract Objectives: Combined chemotherapy and photothermal therapy (PTT) represents a promising approach for enhancing cancer treatment efficacy. This study aimed to develop arsenic trioxide (ATO) and poly(cyclopentadithiophene-alt-benzothiadiazole) (PCPDTBT)-loaded nanoparticles (ATO/PCPDTBT@NPs) to evaluate their synergistic efficacy in inhibiting lung cancer growth and metastasis. Methods: Nanovesicles were synthesized via a streamlined protocol and subjected to 808 nm NIR irradiation to assess their photothermal conversion capabilities. The therapeutic efficacy was evaluated in vitro using A549 lung carcinoma cells to assess apoptosis, invasion, and migration, and in vivo to monitor tumor volume reduction. Results: The nanoparticles exhibited excellent hemocompatibility and low cytotoxicity while More >

Goodness Adediran¹, Kenny Awuson-David², Yussuf Ahmed^1,*

CMC-Computers, Materials & Continua, Vol.87, No.2, 2026, DOI:10.32604/cmc.2026.077606 - 12 March 2026

Abstract Amazon Web Services (AWS) CloudTrail auditing service provides detailed records of operational and security events, enabling cloud administrators to monitor user activity and manage compliance. Although signature-based threat detection methods have been enhanced with machine learning and Large Language Models (LLMs), these approaches remain limited in addressing emerging threats. This study evaluates a two-step Retrieval Augmented Generation (RAG) approach using Gemini 2.5 Pro to enhance threat detection accuracy and contextual relevance. The RAG system integrates external cybersecurity knowledge sources including the MITRE ATT&CK framework, AWS Threat Technique Catalogue, and threat reports to overcome limitations of… More >

Jun Zhang, Jiayi Song, Wangjian Fu, Jiren Yuan^*

Chalcogenide Letters, Vol.23, No.2, 2026, DOI:10.32604/cl.2026.077226 - 28 February 2026

Abstract Tandem solar cells employing lead-free perovskite materials offer a compelling pathway to simultaneously achieve high power conversion efficiency (PCE) and improved environmental sustainability. In this work, we present a comprehensive numerical simulation study of monolithic and mechanically stacked tandem solar cells based on the chalcogenide perovskite BaZrS₃ as the top subcell and Cu(In,Ga)Se₂ (CIGS) as the bottom subcell. For the four-terminal (4-T) configuration, a systematic optimization workflow was implemented, encompassing the thickness of absorber and carrier-transport layers, doping concentrations, and the introduction of a LiF anti-reflection coating. This approach led to a marked reduction in parasitic… More >

Shlomi Barak¹, Netanel Waldenberg¹, Aharon Peretz², Reut Bartoov¹, Guy Bar¹, Snir Dekalo^3,*

Canadian Journal of Urology, Vol.33, No.1, pp. 135-142, 2026, DOI:10.32604/cju.2025.066936 - 28 February 2026

Abstract Background: Hormonal treatment and response as a predictor of sperm retrieval prior to microdissection testicular sperm extraction (micro-TESE) are not well established in the current literature. This study aimed to investigate the hormonal response as a predictor of sperm retrieval among men with nonobstructive azoospermia (NOA). Methods: Seventy-seven consecutive patients who had testosterone levels ≤ 14 nmol/L were treated medically with an aromatase inhibitor or recombinant human chorionic gonadotropin (rec-hCG) prior to micro-TESE and were included. Thirty-four (44.2%) had unexplained NOA (UNEX), 25 (32.5%) had Klinefelter syndrome (KS), 8 (10.4%) had a history of cryptorchidism… More >

Moein Tosan^1,*, Vahid Nourani^2,3, Ozgur Kisi^4,5,6, Yongqiang Zhang⁷, Sameh A. Kantoush⁸, Mekonnen Gebremichael⁹, Ruhollah Taghizadeh-Mehrjardi¹⁰, Jinhui Jeanne Huang¹¹

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.074768 - 29 January 2026

Abstract The integration of machine learning (ML) into geohazard assessment has successfully instigated a paradigm shift, leading to the production of models that possess a level of predictive accuracy previously considered unattainable. However, the black-box nature of these systems presents a significant barrier, hindering their operational adoption, regulatory approval, and full scientific validation. This paper provides a systematic review and synthesis of the emerging field of explainable artificial intelligence (XAI) as applied to geohazard science (GeoXAI), a domain that aims to resolve the long-standing trade-off between model performance and interpretability. A rigorous synthesis of 87 foundational… More >

Farhad Soleimanian Gharehchopogh^*, Keyvan Fattahi Rishakan

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.073808 - 29 January 2026

Abstract Optimization algorithms are crucial for solving NP-hard problems in engineering and computational sciences. Metaheuristic algorithms, in particular, have proven highly effective in complex optimization scenarios characterized by high dimensionality and intricate variable relationships. The Mountain Gazelle Optimizer (MGO) is notably effective but struggles to balance local search refinement and global space exploration, often leading to premature convergence and entrapment in local optima. This paper presents the Improved MGO (IMGO), which integrates three synergistic enhancements: dynamic chaos mapping using piecewise chaotic sequences to boost exploration diversity; Opposition-Based Learning (OBL) with adaptive, diversity-driven activation to speed up… More >

Xun Chen¹, Jinbao Lin^1,2,*, Zai Wang¹

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072495 - 12 January 2026

Abstract This work investigates the effects of deformation mechanisms on the mechanical properties and anisotropy of rolled AZ31B magnesium alloy under uniaxial tension, combining experimental characterization with Visco-Plastic Self Consistent (VPSC) modeling. The research focuses particularly on anisotropic mechanical responses along transverse direction (TD) and rolling direction (RD). Experimental measurements and computational simulations consistently demonstrate that prismatic <a> slip activation significantly reduces the strain hardening rate during the initial stage of tensile deformation. By suppressing the activation of specific deformation mechanisms along RD and TD, the tensile mechanical behavior of the magnesium alloy was further investigated. More >

Zhengwei Li^1,#, Xin Li^2,#, Dong Luo¹, Meijun Liu¹, Luxi Guan¹, Haibo Hu^1,*

Congenital Heart Disease, Vol.20, No.6, pp. 673-682, 2025, DOI:10.32604/chd.2026.069714 - 10 February 2026

Abstract Background: During the surgical repair of complex congenital heart disease (CCHD), a subset of patients is unable to tolerate abrupt postoperative hemodynamic shifts, which can lead to significant complications. To mitigate this risk, certain abnormal venous channels are deliberately left open at the conclusion of surgery to provide a decompressive route, thereby reducing the likelihood of pulmonary hypertensive crises. Nevertheless, the continued patency of these vessels may induce chronic hemodynamic disturbances, often requiring subsequent treatment. This study was designed to assess the safety and efficacy of transcatheter intervention for such persistent anomalous systemic veins in CCHD… More >