Beatrice Sani^1,2, Alessandro Cignetti², Marta Leporati³, Sara Sommariva⁴, Marco Armenio¹, Valerio Tenace⁵, Arianna Savi², Johanna Umurungi^1,2, Giovanni Fornari^1,2, Simone Busso³, Alessandra Canevaro³, Igor Bisognin³, Silvia Marini¹, Michele Piana⁴, Daniela Cilloni^1,2, Valentina Gaidano^2,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.078245 - 16 July 2026

Abstract Objectives: Venetoclax (VEN) is approved for acute myeloid leukemia (AML) in association with azacitidine, in a 28-day schedule at a fixed dosage, which requires reduction if azoles are co-administered. The present study aims to evaluate VEN therapeutic drug monitoring (TDM) in a real-word setting, where the VEN schedule is frequently reduced, investigating: (i) the posaconazole impact, and (ii) whether VEN exposure correlates with safety and efficacy. Methods: We analyzed data from 43 AML patients treated with different VEN-containing regimens, for whom a near-trough VEN plasma concentration (Cmin) was determined at different timepoints (days 5-8-11-15-22-29) across different cycles… More >

Hsing-Ju Wu^1,2, Yu-Chieh Tsai^3,*, Hung-Yu Lin^2,4,*

European Cytokine Network, Vol.37, No.2, pp. 121-135, 2026, DOI:10.32604/ecn.2026.079012 - 30 June 2026

Abstract Backgrounds: Lymph node metastasis is a critical determinant of breast cancer prognosis, yet the specific microenvironmental cytokines driving this process remain elusive. This study aims to identify key prognostic cytokines linking nodal metastasis to tumor microenvironment (TME) remodeling and to evaluate their clinical utility. Methods: A predefined panel of 176 microenvironmental genes was evaluated using differential expression analysis and the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm on the TCGA-BRCA cohort to identify optimal predictors of nodal metastasis. Prognostic value was assessed via Kaplan-Meier, subgroup, and multivariate Cox regression analyses, and validated across five… More > Graphic Abstract

Jerome Gacu^1,2,*, Dencel Edrian Cawaling¹, Edel Queen Fiestada¹, Diablell Maybanting¹, Jamica Bensurto¹, John Kevin Falogme¹, Jea Janelle Fontamillas¹, Janellene Edd Gadon¹, Samaica Fernandez¹, Maryjay Sagario³

Revue Internationale de Géomatique, Vol.35, pp. 373-407, 2026, DOI:10.32604/rig.2026.083180 - 18 June 2026

Abstract A landslide is the downslope movement of soil, rock, or debris driven by gravity, often triggered by natural or anthropogenic factors. The Philippines is highly susceptible to landslides due to its steep terrain, frequent typhoons, intense rainfall, and seismic activity, resulting in significant socioeconomic and environmental impacts. Despite increasing landslide occurrences in vulnerable coastal and mountainous municipalities in the Philippines, localized and integrated Geographic Information System (GIS)-based landslide risk assessments incorporating hazard, vulnerability, and exposure components remain limited in small island municipalities such as San Andres, Romblon. This study assesses landslide risk in the Municipality… More >

Chiara Ferraro¹, Michela Pizzoferrato¹, Michela Graziano¹, Tiziana Servidei², Antonio Ruggiero², Pierluigi Navarra¹, Lucia Lisi^1,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.071074 - 16 June 2026

Abstract Objectives: Advances in molecular profiling of pediatric low-grade glioma have enabled targeted therapies to emerge as effective and better-tolerated alternatives to conventional chemotherapy, increasingly used in progressive or recurrent disease and may reduce long-term treatment toxicity. This study aimed to evaluate the repositioning of the anthelmintic drug mebendazole (MBZ) as an antiproliferative agent in pediatric glioma models, and to investigate potential synergistic effects in combination with vinblastine. Methods: Two well-established human pediatric glioma cell lines, RES 259 and RES 186, were exposed to MBZ alone or in combination with vinblastine. Cell viability, cytotoxicity, and tumor invasiveness… More >

Junming Yan, Boran Xiong, Yingjie Zhu^*

BIOCELL, Vol.50, No.6, 2026, DOI:10.32604/biocell.2026.075319 - 09 June 2026

Abstract Objective: Neural stem cells (NSCs) are essential for replenishing nerve cells, providing neuroprotection, and repairing damaged brain function, while mitophagy is critical for maintaining NSCs’ homeostasis. The study investigated whether pyruvate kinase M2 (PKM2) regulates NSCs’ proliferation and differentiation by modulating mitophagy. Method: This study established a model of excessive autophagy in neural stem cell mitochondria induced by cobalt chloride (CoCl₂) and used plasmid transfection technology to knock down PKM2 expression, examining its effects on NSCs proliferation and differentiation. Additionally, potential mechanisms were explored by overexpressing phosphatase and tensin homolog-induced putative kinase 1 (PINK1) and adding the… More > Graphic Abstract

Qiaoer Li^#, Xiaoting Hou^#, Jingjing Zhao, Shufen Xing^*

International Journal of Mental Health Promotion, Vol.28, No.5, 2026, DOI:10.32604/ijmhp.2026.074860 - 28 May 2026

Abstract Background: Parental overparenting is highly prevalent in current Chinese families, and its psychological influences on adolescent mental health are of great academic and practical concern. However, limited research has examined the potential curvilinear relationship between different dimensions of parental overparenting and adolescent internalizing problems, as well as the moderating roles of adolescent gender and age in these relationships. The purpose of this study was to examine the unique and potentially curvilinear effects of different dimensions of parental overparenting on adolescent internalizing problems in the context of contemporary Chinese families. Methods: Data were collected from 285 adolescents… More >

Manal Mohammed AL-Tamimi^1,2,*, Siti Norul Huda Sheikh Abdullah^1,*, Mohammad Khatim Hasan¹, Mohammed Azmi Al-Betar^3,4, Maw Shin Sim⁵, Abdulrahman Mohammed AL-Tamimi¹

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.2, 2026, DOI:10.32604/cmes.2026.079891 - 27 May 2026

Abstract Pan-cancer survival prediction remains a major challenge in personalized oncology due to profound tumor heterogeneity and the complexity of high-dimensional molecular data. Diverse risk profiles across cancer types and noisy, sparse features hinder deep learning models from capturing robust prognostic patterns. Prior pan-cancer studies predominantly focus on multimodal integration or unimodal gene expression analysis, leaving other informative modalities such as Copy Number Variation (CNV) and miRNA expression underexplored. We introduce a new formulation of mixture-of-experts (MoE) survival modeling that recasts expert assignment as a clinically interpretable risk-space decomposition problem. The proposed framework, CoxGuided-SE, constructs an… More >

Wessam M. Serag El-Din^1,*, Kamal E. Attia¹, Taghreed E. Eissa^2,*, Tarek M. Noor El-Deen², Hadeer Darwish^1,3, Ghadah H. Al Hawas^4,5, Modhi O. Alotaibi^6,7

Phyton-International Journal of Experimental Botany, Vol.95, No.5, 2026, DOI:10.32604/phyton.2026.078357 - 27 May 2026

Abstract Water salinity is a growing environmental concern that significantly impacts soil health, agricultural productivity, and freshwater sustainability, especially in arid regions. This study evaluated the comparative effects of foliar-applied glutathione (GSH) and hydrogen peroxide (H₂O₂) on growth, flower yield, essential oil composition, and physiological responses of Matricaria chamomilla L. under water salinity levels. The experiment was conducted during the 2022/2023 and 2023/2024 seasons at the Experimental Farm of El-Quassassin, Ismailia, Egypt, using a factorial randomized complete block design with three replicates. Foliar applications of GSH (1, 2, and 3 mM) and H₂O₂ (5, 10, and 20 mM)… More >

Daniel Arcuschin de Oliveira¹, Melissa Yoshimi Sakamoto Maeda Nisimoto¹, Jaciara Moreira Sodré Hunnicutt¹, Eduarda Massa Sartori¹, Amanda Fáris Marques¹, Francisco Macedo Paschoal², Luciana Cavalheiro Marti^1,3, Miriam Galvonas Jasiulionis⁴, Miguel Sabino Neto¹, Renato Santos de Oliveira Filho^1,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.077913 - 21 May 2026

Abstract Acral lentiginous melanoma (ALM) is characterized by a low mutational burden, frequent chromosomal rearrangements, and profound epigenetic dysregulation, distinguishing it from ultraviolet (UV)-induced melanoma. Among the epigenetic regulators, Enhancer of Zeste Homolog 2 (EZH2), the catalytic component of the Polycomb Repressive Complex 2 (PRC2), plays a central role in chromatin compaction and transcriptional repression through trimethylation of histone H3 on lysine 27 (H3K27me3). EZH2 overexpression or hyperactivation contributes to tumor progression, immune evasion, and therapeutic resistance. Recent multi-omic studies have highlighted the importance of EZH2 in regulating melanoma plasticity, immune modulation, and metabolic reprogramming. In… More > Graphic Abstract

Shunpeng Yang¹, Yunpeng Wu¹, Wenwen Qin¹, Cheng Yang^2,*, Yu Qian³

Structural Durability & Health Monitoring, Vol.20, No.3, 2026, DOI:10.32604/sdhm.2026.077878 - 18 May 2026

Abstract To enhance traffic infrastructure health monitoring via computer vision (CV) in adverse weather conditions, image dehazing has emerged as a critical processing step. However, current supervised dehazing models, typically trained on synthetic hazy-clean image pairs, often demonstrate limited generalization ability when deployed in real-world haze scenarios. This study proposes a novel unsupervised dehazing framework named the unpaired dual-domain dehazing network (UD³Net). Initially, a novel dual-domain convolutional mixer (DCM) is developed, which can extract local features in the spatial domain and global features in the frequency domain to achieve thorough information fusion, aiming to facilitate accurate estimation… More >