Hongbo Sun*1,
Zhifu Zhang*1,
Wei Luo*, Junmin Liu*, Ye Lou†, Shengmei Xia‡
Oncology Research, Vol.27, No.8, pp. 935-944, 2019, DOI:10.3727/096504019X15555388198071
Abstract Acute lymphoblastic leukemia (ALL) is the most prevalent of pediatric cancers. Neuroepithelial cell-transforming 1
(NET1) has been associated with malignancy in a number of cancers, but the role of NET1 in ALL development is unclear. In the present study, we investigated the effect of NET1 gene in ALL cell proliferation and
chemoresistance. We analyzed GEO microarray data comparing bone marrow expression profiles of pediatric
B-cell ALL samples and those of age-matched controls. MTT and colony formation assays were performed
to analyze cell proliferation. ELISA assays, Western blot analyses, and TUNEL staining were used to detect
chemoresistance. We confirmed that NET1… More >
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