LIJUN DU1, KAIKAI DOU1, NIANHAI LIANG1,2, JIANMIN SUN1, RU BAI1,*
BIOCELL, Vol.47, No.3, pp. 547-554, 2023, DOI:10.32604/biocell.2023.025048
Abstract Background: The Warburg effect is considered as a hallmark of various types of cancers, while the regulatory
mechanism is poorly understood. Our previous study demonstrated that miR-194-5p directly targets and regulates
insulin-like growth factor1 receptor (IGF1R). In this study, we aimed to investigate the role of miR-194-5p in the
regulation of the Warburg effect in ovarian cancer cells. Methods: The stable ovarian cell lines with miR-194-5p
overexpression or silencing IGF1R expression were established by lentivirus infection. ATP generation, glucose uptake,
lactate production and extracellular acidification rate (ECAR) assay were used to analyze the effects of aerobic glycolysis
in ovarian cancer… More >
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