YONGLI ZHANG1,#, YIZHAN CAO2,#, BO ZHU3, YANNI JIANG3, PENGCHONG LIANG3,*
BIOCELL, Vol.45, No.1, pp. 41-48, 2021, DOI:10.32604/biocell.2021.010454
Abstract Glycosylation of mucins mediated by N-acetylgalactosaminyltransferases (GALNTs) is closely related to
respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). In addition, long non-coding
RNAs (LncRNAs) participate in physiological and pathological processes through various epigenetic mechanisms. In
this study, we found that a novel LncRNA named NKILA combined with multiple mucins and GALNTs potentially
by several bioinformatics methods, and we used quantitative real-time PCR (RT-qPCR) to detect the expressions of
NKILA, MUC5AC, MUC5B, and GALNT2 mRNA in 50 cases of asthma samples and 19 cases of normal samples,
whose results showed that the expression of NKILA was significantly… More >
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