EMILIA MANOLE1,2,#, LAURA DUMITRESCU2,3,#, CRISTINA NICULIȚE1,3, BOGDAN OVIDIU POPESCU1,2,3, LAURA CRISTINA CEAFALAN1,3,*
BIOCELL, Vol.45, No.1, pp. 1-16, 2021, DOI:10.32604/biocell.2021.013452
Abstract An increasing number of studies provide evidence for the existence of a microbiota-gut-brain axis and its
potential involvement in the development of sporadic Parkinson’s disease and other neurodegenerative conditions.
The neuropathologic hallmark of Parkinson’s disease is the presence of brain intraneuronal aggregates of misfolded
alpha-synuclein, known as Lewy bodies. Some gut microbiota products may trigger alpha-synuclein conformational
changes in the neurons of the enteric nervous system, which can then spread to the brain in a prion-like fashion
through the vagus nerve. Others may interfere with neuroinflammatory pathways and susceptibility to
neurodegeneration. In this review, we assess the potential role of… More >
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